SCHEMBL1132599

SCHEMBL1132599

COc1ccc(Cl)c2ncccc12

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
G6PD P11413 1/20 0.54
KDM4E B2RXH2 7/20 0.53
CYP3A4 P08684 3/20 0.53
ALOX12 P18054 1/20 0.53
TDP1 Q9NUW8 1/20 0.53
GAA P10253 1/20 0.49
MAPT P10636 4/20 0.47
LMNA P02545 2/20 0.47
BRD4 O60885 1/20 0.47
HSP90AA1 P07900 1/20 0.47
METAP2 P50579 1/20 0.47
METAP1 P53582 1/20 0.47
HTT P42858 3/20 0.47
PDE4A P27815 2/20 0.47
PDE4B Q07343 2/20 0.47
PDE4C Q08493 2/20 0.47
PDE4D Q08499 2/20 0.47
HSD17B10 Q99714 1/20 0.47
PKM P14618 1/20 0.47
NSD2 O96028 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6589147 0.86 NR4A2 (0.56) G6PDKDM4EHTTHSD17B10NSD2
SCHEMBL2770506 0.86 KDM4E (0.65) G6PDKDM4ECYP3A4ALOX12TDP1
SCHEMBL1506959 0.85 HTR1A (0.53) G6PDKDM4EGAAHSP90AA1HTT
SCHEMBL13036181 0.80 KMT2A (0.50) G6PDKDM4ETDP1MAPTHSP90AA1
SCHEMBL625749 0.79 NSD2 (0.62) G6PDMAPTLMNAHSP90AA1HTT
SCHEMBL12566073 0.79 NSD2 (0.54) G6PDKDM4ETDP1MAPTLMNA
SCHEMBL2224753 0.79 HSP90AA1 (0.62) KDM4EALOX12TDP1GAAMAPT
SCHEMBL12599430 0.79 SYK (0.47) G6PDKDM4ETDP1GAAMAPT
SCHEMBL196536 0.78 KDM4E (0.70) KDM4ECYP3A4ALOX12TDP1GAA
Hydrochloric Acid SCHEMBL20589073 0.77 NSD2 (0.60) G6PDMAPTLMNAHSP90AA1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110003271-B Process for producing aromatic compound 住友化学株式会社 2022-05-03 CN disclosed
US-11045796-B2 Process for producing aromatic compound, and palladium complex SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2021-06-29 US disclosed
CN-108368142-B Method for producing aromatic compound and palladium complex 住友化学株式会社 2021-02-19 CN disclosed
CN-110003271-A The preparation method of aromatic compound 住友化学株式会社 2019-07-12 CN disclosed
US-20180369799-A1 PROCESS FOR PRODUCING AROMATIC COMPOUND, AND PALLADIUM COMPLEX SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2018-12-27 US disclosed
EP-3385270-A1 METHOD FOR PRODUCING AROMATIC COMPOUND, AND PALLADIUM COMPLEX Sumitomo Chemical Company, Ltd (JP) 2018-10-10 EP disclosed
US-20180200253-A1 Heteroaromatic Compounds and their Use as Dopamine D1 Ligands PFIZER INC. (US) 2018-07-19 US disclosed
US-9982087-B2 Method for producing compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2018-05-29 US disclosed
EP-3323821-A1 HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS Pfizer Inc (US) 2018-05-23 EP disclosed
EP-2871199-B1 METHOD FOR PRODUCING AROMATIC COMPOUND SUMITOMO CHEMICAL CO (JP) 2018-02-21 EP disclosed
WO-2014072881-A1 HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS PFIZER INC. (US) 2014-05-15 WO disclosed
CN-102015585-B Method for producing unsaturated organic compound SUMITOMO CHEMICAL CO 2013-06-19 CN disclosed
US-8237002-B2 Method for producing unsaturated organic compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-08-07 US disclosed
CN-102015585-A Method for producing unsaturated organic compound SUMITOMO CHEMICAL CO 2011-04-13 CN disclosed
US-20110046380-A1 METHOD FOR PRODUCING UNSATURATED ORGANIC COMPOUND SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-02-24 US disclosed
EP-2287141-A1 METHOD FOR PRODUCING UNSATURATED ORGANIC COMPOUND Sumitomo Chemical Company, Limited (JP) 2011-02-23 EP disclosed
US-20060111593-A1 Coupling catalyst and process using the same SUMITOMO CHEMICAL COMPANY, LIMITED 2006-05-25 US disclosed
US-7041856-B2 Coupling catalyst and process using the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-05-09 US disclosed
US-20030162950-A1 Coupling catalyst and process using the same SUMITOMO CHEMICAL COMPANY, LIMITED 2003-08-28 US disclosed
EP-1306131-A2 Cross-Coupling catalyst comprising a cyclic nitrogen ligand and process using the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2003-05-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030162950-A1 Coupling catalyst and process using the same NOD1, PYM1, C9 G6PD 3767/4885KDM4E 3633/4885CYP3A4 2291/4885
US-11045796-B2 Process for producing aromatic compound, and palladium complex DDT, DRD1, DRD2 G6PD 1526/4885KDM4E 969/4885CYP3A4 148/4885
US-20180200253-A1 Heteroaromatic Compounds and their Use as Dopamine D1 Ligands COMT, DRD2, NR3C1 G6PD 330/4885KDM4E 3804/4885CYP3A4 821/4885
US-20060111593-A1 Coupling catalyst and process using the same RPL22, C9, RBM22 G6PD 4375/4885KDM4E 2604/4885CYP3A4 1666/4885
US-20110046380-A1 METHOD FOR PRODUCING UNSATURATED ORGANIC COMPOUND NIT2, NOS1, CHRM1 G6PD 4565/4885KDM4E 4610/4885CYP3A4 2700/4885
US-20180369799-A1 PROCESS FOR PRODUCING AROMATIC COMPOUND, AND PALLADIUM COMPLEX DDT, DRD1, DRD2 G6PD 1526/4885KDM4E 969/4885CYP3A4 148/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.