Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.49 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | NSD2 | O96028 | 1/20 | 0.47 |
| ▸ | CASP6 | P55212 | 1/20 | 0.47 |
| ▸ | G6PD | P11413 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MMP14 | P50281 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1506959 | 0.86 | HTR1A (0.53) | KMT2AMEN1HTTHSP90AA1NPC1 | |
| SCHEMBL8277995 | 0.85 | HTR1A (0.53) | PSMD14COPS5CCR1CCR8 | |
| SCHEMBL3147583 | 0.85 | PSMD14 (0.58) | KMT2AMEN1HTTPSMD14COPS5 | |
| SCHEMBL12180599 | 0.81 | MEN1 (0.50) | KMT2AMEN1SMN1; SMN2HTTPSMD14 | |
| SCHEMBL12599430 | 0.80 | SYK (0.47) | KMT2AMEN1SMN1; SMN2HTTHSP90AA1 | |
| SCHEMBL1132599 | 0.80 | G6PD (0.54) | SMN1; SMN2HTTHSP90AA1NPC1L3MBTL1 | |
| SCHEMBL12566073 | 0.80 | NSD2 (0.54) | KMT2AMEN1SMN1; SMN2HTTHSP90AA1 | |
| SCHEMBL625749 | 0.80 | NSD2 (0.62) | KMT2AMEN1HTTHSP90AA1NPC1 | |
| SCHEMBL2224753 | 0.80 | HSP90AA1 (0.62) | KMT2AMEN1SMN1; SMN2HTTSLC6A2 | |
| SCHEMBL812451 | 0.80 | HTT (0.70) | KMT2AMEN1SMN1; SMN2HTTPSMD14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3245191-B1 | QUINOLINES AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2020-09-30 | — | — | EP | disclosed |
| CN-107721920-B | Synthesis method of quinoline amide compound | 济南大学 | 2020-07-07 | — | — | CN | disclosed |
| WO-2019215426-A1 | PROCESS FOR FORMING A CARBON-CARBON BOND | THE UNIVERSITY OF MANCHESTER (GB) | 2019-11-14 | — | — | WO | disclosed |
| WO-2019215427-A1 | PROCESS FOR FORMING A CARBON-CARBON BOND | THE UNIVERSITY OF MANCHESTER (GB) | 2019-11-14 | — | — | WO | disclosed |
| US-10144712-B2 | Quinolines and process for the preparation thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2018-12-04 | — | — | US | disclosed |
| US-20180009759-A1 | Quinolines and Process for the Preparation Thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2018-01-11 | — | — | US | disclosed |
| US-8841331-B2 | Inhibitors of human immunodeficiency virus replication | GILEAD SCIENCES, INC. (US) | 2014-09-23 | — | — | US | disclosed |
| US-8841331-B2 | Inhibitors of human immunodeficiency virus replication | GILEAD SCIENCES, INC. (US) | 2014-09-23 | — | — | US | disclosed |
| US-8338441-B2 | Inhibitors of human immunodeficiency virus replication | GILEAD SCIENCES, INC. (US) | 2012-12-25 | — | — | US | disclosed |
| US-8338441-B2 | Inhibitors of human immunodeficiency virus replication | GILEAD SCIENCES, INC. (US) | 2012-12-25 | — | — | US | disclosed |
| WO-2010130034-A1 | INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-11-18 | — | — | WO | disclosed |
| US-20100292227-A1 | INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | BOEHRINGER INGLEHEIM INTERNATIONAL GMBH (DE) | 2010-11-18 | — | — | US | disclosed |
| US-20100292227-A1 | INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | BOEHRINGER INGLEHEIM INTERNATIONAL GMBH (DE) | 2010-11-18 | — | — | US | disclosed |
| US-20080015190-A1 | Inhibitors of Histone Deacetylase | MERCK SHARP & DOHME CORP. | 2008-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180009759-A1 | Quinolines and Process for the Preparation Thereof | NQO1, NQO2, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | KMT2A 147/4885MEN1 425/4885SMN1; SMN2 4331/4885 |
| US-20100292227-A1 | INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | RTF2, REV1, RTF1 | KMT2A 2329/4885MEN1 3840/4885SMN1; SMN2 4172/4885 |
| US-10144712-B2 | Quinolines and process for the preparation thereof | NQO1, NQO2, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | KMT2A 147/4885MEN1 425/4885SMN1; SMN2 4331/4885 |
| US-20080015190-A1 | Inhibitors of Histone Deacetylase | HDAC5, HDAC1, HDAC4 | KMT2A 55/4885MEN1 3547/4885SMN1; SMN2 1474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.