Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 5/20 | 0.42 |
| ▸ | PPARA | Q07869 | 5/20 | 0.42 |
| ▸ | PPARD | Q03181 | 2/20 | 0.42 |
| ▸ | ACE | P12821 | 3/20 | 0.40 |
| ▸ | MME | P08473 | 1/20 | 0.40 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8310911 | 0.80 | GPR139 (0.51) | GPR139PPARGPPARAPPARDKMT2A | |
| SCHEMBL8310917 | 0.80 | GPR139 (0.51) | GPR139PPARGPPARAPPARDKMT2A | |
| SCHEMBL11331818 | 0.80 | ACE (0.43) | GPR139PPARGPPARAPPARDACE | |
| SCHEMBL20122472 | 0.79 | ALDH1A1 (0.42) | PPARGPPARAACEMMEACE2 | |
| SCHEMBL20122473 | 0.79 | MAPT (0.46) | ACEMMEACE2KMT2AALDH1A1 | |
| SCHEMBL10942540 | 0.79 | PTPN1 (0.50) | GPR139PPARGPPARAACE | |
| SCHEMBL10805856 | 0.79 | PTPN1 (0.50) | GPR139PPARGPPARAACE | |
| SCHEMBL9300974 | 0.78 | GPR139 (0.44) | GPR139PPARGPPARAPPARDACE | |
| SCHEMBL20122445 | 0.77 | ADRB2 (0.41) | PPARGPPARAPPARDACEMME | |
| SCHEMBL24779170 | 0.76 | GPR139 (0.50) | GPR139ACEMMEACE2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4255446-A | SUPPRESSING LIVER DISORDERS | SANTEN PHARMACEUTICAL CO. LTD. (JP) | 1981-03-10 | — | — | US | claimed |
| US-4255446-A | SUPPRESSING LIVER DISORDERS | SANTEN PHARMACEUTICAL CO. LTD. (JP) | 1981-03-10 | — | — | US | disclosed |