Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 5/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.40 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 2/20 | 0.40 |
| ▸ | MMP13 | P45452 | 2/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL1133667 | 1.00 | CA2 (0.52) | CA2CA1TP53GPR84NFKB1 | |
| SCHEMBL26969246 | 0.96 | CA2 (0.56) | CA2CA1TP53GPR84NFKB1 | |
| SCHEMBL30424973 | 0.96 | CA2 (0.56) | CA2CA1TP53GPR84NFKB1 | |
| SCHEMBL3932122 | 0.96 | CA2 (0.56) | CA2CA1TP53GPR84NFKB1 | |
| SCHEMBL247523 | 0.96 | CA2 (0.56) | CA2CA1TP53GPR84NFKB1 | |
| SCHEMBL11699305 | 0.96 | CA2 (0.56) | CA2CA1TP53GPR84NFKB1 | |
| SCHEMBL66700 | 0.96 | CA2 (0.56) | CA2CA1TP53GPR84NFKB1 | |
| SCHEMBL2123672 | 0.96 | CA2 (0.56) | CA2CA1TP53GPR84NFKB1 | |
| SCHEMBL8022640 | 0.96 | CA2 (0.56) | CA2CA1TP53GPR84NFKB1 | |
| SCHEMBL5167672 | 0.86 | ZDHHC7 (0.47) | CA2CA1TP53GPR84NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2455157-B1 | SOLUBILIZER FOR COSMETIC PREPARATIONS | SYMRISE AG (DE) | 2016-03-23 | — | — | EP | disclosed |
| EP-2455157-A1 | Solubilizer for cosmetic preparations | Symrise AG (DE) | 2012-05-23 | — | — | EP | disclosed |
| EP-2286908-A2 | Solubilizer for cosmetic preparations | Symrise AG (DE) | 2011-02-23 | — | — | EP | disclosed |