Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | FABP7 | O15540 | 1/20 | 0.44 |
| ▸ | FABP3 | P05413 | 1/20 | 0.44 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ESRRA | P11474 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 6/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18540824 | 0.77 | NQO1 (0.46) | ALDH1A1KDM4EHPGDHSD17B10FABP7 | |
| SCHEMBL18129645 | 0.76 | MTNR1B (0.54) | ALDH1A1KDM4EMEN1KMT2AGAA | |
| SCHEMBL1134739 | 0.75 | NQO1 (0.44) | ALDH1A1KDM4EHPGDHSD17B10MEN1 | |
| SCHEMBL28010783 | 0.75 | MTNR1A (0.60) | ALDH1A1CYP3A4ALOX5TSHRMEN1 | |
| SCHEMBL7912909 | 0.75 | CYP3A4 (0.60) | ALDH1A1KDM4EHSD17B10CYP3A4ALOX5 | |
| SCHEMBL10282867 | 0.74 | ALDH1A1 (0.60) | ALDH1A1KDM4EHPGDHSD17B10MEN1 | |
| SCHEMBL3163561 | 0.73 | KDM4E (0.51) | ALDH1A1KDM4EHPGDHSD17B10CYP3A4 | |
| SCHEMBL30203238 | 0.73 | KDM4E (0.51) | ALDH1A1KDM4EHPGDHSD17B10CYP3A4 | |
| SCHEMBL24973122 | 0.73 | ALDH1A1 (0.53) | ALDH1A1KDM4EHPGDHSD17B10CYP3A4 | |
| SCHEMBL28858601 | 0.73 | LCK (0.56) | ALDH1A1KDM4EHPGDHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492425-B2 | 5-methyl-1-(naphthalen-2-yl)-1H-pyrazoles useful as sigma receptor inhibitors | LABORATORIES DEL DR. ESTEVE, S.A. (ES) | 2013-07-23 | — | — | US | disclosed |
| US-20110118253-A1 | 5-METHYL-1-(NAPHTHALEN-2-YL)-1H-PYRAZOLES USEFUL AS SIGMA RECEPTOR INHIBITORS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2011-05-19 | — | — | US | disclosed |
| EP-2285781-A1 | 5-METHYL-1-(NAPHTHALEN-2-YL)-1H-PYRAZOLES USEFUL AS SIGMA RECEPTOR INHIBITORS | Laboratorios del Dr. Esteve S.A. (ES) | 2011-02-23 | — | — | EP | disclosed |
| EP-2113501-A1 | 5-Methyl-1-(naphthalen-2-YL)-1H-Pyrazoles useful as sigma receptor inhibitors | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2009-11-04 | — | — | EP | disclosed |
| WO-2009130331-A1 | 5-METHYL-1-(NAPHTHALEN-2-YL)-1H-PYRAZOLES USEFUL AS SIGMA RECEPTOR INHIBITORS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2009-10-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118253-A1 | 5-METHYL-1-(NAPHTHALEN-2-YL)-1H-PYRAZOLES USEFUL AS SIGMA RECEPTOR INHIBITORS | SIGMAR1, OPRM1, OPRK1 | ALDH1A1 654/4885KDM4E 3580/4885HPGD 398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.