Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2646586 | 0.80 | ALOX5 (0.62) | RAB9AMAPTKMT2ALMNAHTT | |
| Trinitrophenol SCHEMBL1134872 | 0.80 | RAB9A (0.51) | RAB9AMAPTKMT2ALMNAHTT | |
| SCHEMBL2562637 | 0.75 | ALDH1A1 (0.53) | RAB9AMAPTKMT2ALMNAHTT | |
| SCHEMBL27554309 | 0.72 | SMN1; SMN2 (0.56) | RAB9AMAPTHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL8761996 | 0.71 | HCAR3 (0.50) | RAB9AMAPTKMT2AHTTMEN1 | |
| SCHEMBL10424957 | 0.71 | ALOX5 (0.67) | RAB9AMAPTKMT2ALMNAHTT | |
| SCHEMBL11125491 | 0.71 | CA1 (0.51) | MAPTKMT2ALMNAHTTMEN1 | |
| SCHEMBL6160168 | 0.71 | RAB9A (0.66) | RAB9AMAPTKMT2ALMNAMEN1 | |
| SCHEMBL8534736 | 0.71 | RAB9A (0.87) | RAB9AMAPTKMT2ALMNAHTT | |
| SCHEMBL28891518 | 0.70 | SMN1; SMN2 (0.54) | RAB9AMAPTHTTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 105 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083628-B1 | FUSED IMIDAZOLYL DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | ESTEVE PHARMACEUTICALS SA (ES) | 2019-08-07 | — | — | EP | disclosed |
| EP-2817309-B1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINES, THEIR PREPARATION AND USE AS MEDICAMENTS | ESTEVE LABOR DR (ES) | 2018-06-20 | — | — | EP | disclosed |
| US-9789117-B2 | Use of sigma ligands in diabetes type-2 associated pain | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2017-10-17 | — | — | US | disclosed |
| EP-1781272-B1 | USE OF COMPOUNDS ACTIVE ON THE SIGMA RECEPTOR FOR THE TREATMENT OF MECHANICAL ALLODYNIA | ESTEVE LABOR DR (ES) | 2017-09-06 | — | — | EP | disclosed |
| CN-104254535-B | Substituted pyrazolo [1,5 a] pyridine, its prepare and be used as the application of medicine | 埃斯蒂文博士实验室股份有限公司 | 2017-07-14 | — | — | CN | disclosed |
| US-9676784-B2 | Fused imidazolyl derivatives, their preparation and use as medicaments | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2017-06-13 | — | — | US | disclosed |
| EP-2066648-B1 | SUBSTITUTED DIMETHYLCYCLOBUTYL COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | ESTEVE LABOR DR (ES) | 2017-04-12 | — | — | EP | disclosed |
| US-9617281-B2 | Imidazo[2,1-b]thiazole derivatives, their preparation and use as medicaments | LABORATORIES DEL DR. ESTEVE S.A. (ES) | 2017-04-11 | — | — | US | disclosed |
| EP-2986616-B1 | TRICYCLIC TRIAZOLIC COMPOUNDS AS SIGMA RECEPTORS LIGANS | ESTEVE LABOR DR (ES) | 2017-03-29 | — | — | EP | disclosed |
| EP-2807169-B1 | SUBSTITUTED PYRANO AND FURANOQUINOLINES, THEIR PREPARATION AND USE AS MEDICAMENTS | ESTEVE LABOR DR (ES) | 2017-03-01 | — | — | EP | disclosed |
| WO-2006069807-A1 | SUBSTITUTED PHENYL-PIPERAZINE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2006-07-06 | — | — | WO | disclosed |
| WO-2006069806-A1 | PHARMACEUTICAL COMPOSITION COMPRINSING A 2,5-DIHYDROXYBENZENESULFONIC COMPOUNDS, A POTASSIUM ION CHANNEL MODULATOR AND A PHOSPHODIESTERASE TYPE 5 INHIBITOR | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2006-07-06 | — | — | WO | disclosed |
| WO-2006069809-A1 | SUBSTITUTED INDAZOLYL SULFONAMIDE AND 2,3-DIHYDRO-INDOLYL SULFONAMIDE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2006-07-06 | — | — | WO | disclosed |
| EP-1676841-A1 | Substitited indazolyl sulfonamide and 2,3-dihydro-indolyl sulfonamide compounds, their prepartion and use in medicaments | Esteve Laboratorios Dr. Esteve S.A. (ES) | 2006-07-05 | — | — | EP | disclosed |
| EP-1676573-A1 | Phamaceutical composition comprising a 2,5-dihydroxybenzenesulfonic-compound, a potassium ion channel modulator and a phosphodiesterase type 5 inhibitor | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2006-07-05 | — | — | EP | disclosed |
| EP-1676842-A1 | Nitro-substituted phenyl-piperazine compounds, their preparation and use in medicaments | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2006-07-05 | — | — | EP | disclosed |
| EP-1652521-A1 | Pharmaceutical composition of sildenafil and a large conductance Ca(2+) activated K+ channels activator | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2006-05-03 | — | — | EP | disclosed |
| WO-2006010587-A1 | USE OF COMPOUNDS ACTIVE ON THE SIGMA RECEPTOR FOR THE TREATMENT OF MECHANICAL ALLODYNIA | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2006-02-02 | — | — | WO | disclosed |
| US-20060019969-A1 | Use of compounds active on the sigma receptor for the treatment of allodynia | LABORATORIOS DR. ESTEVE S.A. (ES) | 2006-01-26 | — | — | US | disclosed |
| US-20060019968-A1 | Use of compounds active on the sigma receptor for the treatment of neuropathic pain | LABORATORIOS DR. ESTEVE S.A. (ES) | 2006-01-26 | — | — | US | disclosed |