Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 6/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10424957 | 0.81 | ALOX5 (0.67) | ALOX5MEN1KMT2ALMNAHTT | |
| SCHEMBL27554309 | 0.80 | SMN1; SMN2 (0.56) | HTTMAPTRAB9AALDH1A1GAA | |
| SCHEMBL1134873 | 0.80 | RAB9A (0.58) | MEN1KMT2ALMNAHTTMAPT | |
| SCHEMBL1578589 | 0.79 | KMT2A (0.95) | ALOX5MEN1KMT2ALMNAHTT | |
| SCHEMBL28989406 | 0.78 | MGLL (0.58) | ALOX5MEN1KMT2AMAPTRAB9A | |
| SCHEMBL28891518 | 0.78 | SMN1; SMN2 (0.54) | HTTMAPTRAB9AALDH1A1GAA | |
| SCHEMBL11340446 | 0.78 | PKM (0.56) | ALOX5MEN1KMT2ALMNAHTT | |
| SCHEMBL27182272 | 0.78 | KMT2A (0.88) | ALOX5MEN1KMT2ALMNAHTT | |
| SCHEMBL455174 | 0.77 | ALOX5 (0.72) | ALOX5MEN1KMT2ALMNAHTT | |
| SCHEMBL27935077 | 0.77 | ALOX5 (1.00) | ALOX5MEN1KMT2ALMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6255305-B1 | PSYCHOLOGICAL DISORDERS | MERCK SHARP & DOHME LIMITED (GB) | 2001-07-03 | — | — | US | disclosed |
| EP-0915875-A2 | SUBSTITUTED TRIAZOLO-PYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 1999-05-19 | — | — | EP | disclosed |
| WO-1998004559-A2 | SUBSTITUTED TRIAZOLO-PYRIDAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 1998-02-05 | — | — | WO | disclosed |
| US-5118690-A | PHARMACEUTICAL TETRAHYDROISOQUINOLINES | JOHN WYETH & BROTHER LIMITED (GB) | 1992-06-02 | — | — | US | disclosed |