Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6829889 | 0.81 | LMNA (0.46) | ALDH1A1HPGDLMNAL3MBTL1MEN1 | |
| SCHEMBL24445379 | 0.81 | LMNA (0.46) | ALDH1A1HPGDLMNAL3MBTL1MEN1 | |
| SCHEMBL7823667 | 0.76 | KEAP1 (0.40) | ALDH1A1TDP1KEAP1NFE2L2SMN1; SMN2 | |
| SCHEMBL7402778 | 0.76 | KEAP1 (0.40) | ALDH1A1TDP1KEAP1NFE2L2SMN1; SMN2 | |
| SCHEMBL8594253 | 0.75 | TDP1 (0.47) | ALDH1A1MAPTTDP1KEAP1NFE2L2 | |
| SCHEMBL8594247 | 0.75 | TDP1 (0.47) | ALDH1A1MAPTTDP1KEAP1NFE2L2 | |
| SCHEMBL11186390 | 0.72 | ALDH1A1 (0.39) | ALDH1A1TDP1KEAP1NFE2L2SMN1; SMN2 | |
| SCHEMBL29940797 | 0.71 | L3MBTL1 (0.43) | ALDH1A1TDP1KEAP1NFE2L2L3MBTL1 | |
| SCHEMBL15965560 | 0.69 | HPGD (0.44) | ALDH1A1MAPTTDP1KEAP1NFE2L2 | |
| SCHEMBL6203868 | 0.69 | CHRNA7 (0.41) | ALDH1A1MAPTTDP1KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4255445-A | DOPAMINERGIC ACTIVITY, RENAL VASODILATING ACTIVITY | SMITHKLINE CORPORATION (US) | 1981-03-10 | — | — | US | disclosed |