Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7402778 | 1.00 | KEAP1 (0.40) | KEAP1NFE2L2CHRNA7ACHETDP1 | |
| SCHEMBL11186390 | 0.77 | ALDH1A1 (0.39) | KEAP1NFE2L2CHRNA7ACHETDP1 | |
| SCHEMBL24445380 | 0.77 | LMNA (0.56) | LMNAALDH1A1HPGDMAPK1TSHR | |
| SCHEMBL29392498 | 0.77 | LMNA (0.56) | LMNAALDH1A1HPGDMAPK1TSHR | |
| SCHEMBL245404 | 0.76 | LMNA (0.62) | KEAP1NFE2L2ACHELMNAALDH1A1 | |
| SCHEMBL11158181 | 0.76 | MEN1 (0.38) | TDP1LMNAALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL245405 | 0.76 | LMNA (0.62) | KEAP1NFE2L2ACHELMNAALDH1A1 | |
| SCHEMBL366066 | 0.76 | LMNA (0.62) | KEAP1NFE2L2ACHELMNAALDH1A1 | |
| SCHEMBL11358787 | 0.76 | ALDH1A1 (0.40) | KEAP1NFE2L2CHRNA7ACHETDP1 | |
| SCHEMBL4104447 | 0.71 | CYP3A4 (0.47) | KEAP1NFE2L2CHRNA7ACHETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1091958-A1 | SALTS OF PAROXETINE | SMITHKLINE BEECHAM PLC (GB) | 2001-04-18 | — | — | EP | disclosed |
| WO-2000001692-A1 | SALTS OF PAROXETINE | SMITHKLINE BEECHAM PLC (GB) | 2000-01-13 | — | — | WO | disclosed |