Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11384600 | 0.89 | KDR (0.32) | RIPK1 | |
| SCHEMBL11374129 | 0.87 | KDR (0.35) | — | |
| SCHEMBL11383035 | 0.83 | S1PR1 (0.33) | RIPK1CNR2 | |
| SCHEMBL11380256 | 0.82 | KDR (0.34) | RIPK1CNR2 | |
| SCHEMBL11381891 | 0.82 | CNR1 (0.37) | RIPK1CNR2 | |
| SCHEMBL11491168 | 0.78 | RIPK1 (0.36) | RIPK1 | |
| SCHEMBL11376381 | 0.78 | ALDH1A1 (0.47) | RIPK1 | |
| SCHEMBL11596461 | 0.77 | — | — | |
| SCHEMBL11381411 | 0.74 | RIPK1 (0.32) | RIPK1 | |
| SCHEMBL11381422 | 0.74 | RIPK1 (0.32) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4243674-A | HYPOTENSIVE AGENTS; ANALGESICS; ANTISECRETORY AGENTS; ANTIBODY INHIBITORS, AND TRANQUILIZERS | PFIZER INC. (US) | 1981-01-06 | — | — | US | disclosed |
| US-4143139-A | ANALGESICS, HYPOTENSIVES, IMMUNOSUPPRESSANTS, TRANQUILIZERS, ANTISECRETORY, ANTI-ANXIETY | PFIZER INC. (US) | 1979-03-06 | — | — | US | disclosed |