Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 11/20 | 0.37 |
| ▸ | CNR2 | P34972 | 11/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.36 |
| ▸ | TRPV3 | Q8NET8 | 3/20 | 0.36 |
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.36 |
| ▸ | TRPV2 | Q9Y5S1 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.35 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.35 |
| ▸ | TRPV5 | Q9NQA5 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.35 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11384600 | 0.86 | KDR (0.32) | RIPK1 | |
| SCHEMBL31545431 | 0.85 | CNR2 (0.51) | CNR1CNR2TRPA1TRPV1TRPV3 | |
| SCHEMBL11374129 | 0.84 | KDR (0.35) | — | |
| SCHEMBL11575956 | 0.82 | OPRM1 (0.34) | CNR1CNR2TRPA1TRPV1TRPV3 | |
| SCHEMBL11491168 | 0.82 | RIPK1 (0.36) | CYP19A1CYP1A2RIPK1 | |
| SCHEMBL11375232 | 0.82 | RIPK1 (0.31) | CNR2RIPK1 | |
| SCHEMBL11380256 | 0.75 | KDR (0.34) | CNR2RIPK1 | |
| SCHEMBL11478506 | 0.73 | MAOB (0.34) | CYP19A1 | |
| SCHEMBL11381814 | 0.72 | ALDH1A1 (0.60) | MEN1KMT2ARIPK1 | |
| SCHEMBL11372707 | 0.67 | CNR2 (0.42) | CNR1CNR2TRPA1TRPV1TRPV3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4243674-A | HYPOTENSIVE AGENTS; ANALGESICS; ANTISECRETORY AGENTS; ANTIBODY INHIBITORS, AND TRANQUILIZERS | PFIZER INC. (US) | 1981-01-06 | — | — | US | disclosed |
| US-4143139-A | ANALGESICS, HYPOTENSIVES, IMMUNOSUPPRESSANTS, TRANQUILIZERS, ANTISECRETORY, ANTI-ANXIETY | PFIZER INC. (US) | 1979-03-06 | — | — | US | disclosed |