Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11379786 | 0.87 | ALDH1A1 (0.52) | ALDH1A1RAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL11383830 | 0.85 | ALDH1A1 (0.50) | ALDH1A1RAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL11381411 | 0.80 | RIPK1 (0.32) | RIPK1MAOB | |
| SCHEMBL11381422 | 0.80 | RIPK1 (0.32) | RIPK1MAOB | |
| SCHEMBL11387518 | 0.79 | RAB9A (0.49) | ALDH1A1RAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL11381814 | 0.79 | ALDH1A1 (0.60) | ALDH1A1RAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL11375232 | 0.78 | RIPK1 (0.31) | RIPK1 | |
| SCHEMBL11376592 | 0.76 | RAB9A (0.55) | ALDH1A1RAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL11786922 | 0.75 | ALDH1A1 (0.48) | ALDH1A1RAB9ANPC1LMNASMN1; SMN2 | |
| SCHEMBL11382132 | 0.75 | ALDH1A1 (0.48) | ALDH1A1RAB9ANPC1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4243674-A | HYPOTENSIVE AGENTS; ANALGESICS; ANTISECRETORY AGENTS; ANTIBODY INHIBITORS, AND TRANQUILIZERS | PFIZER INC. (US) | 1981-01-06 | — | — | US | disclosed |
| US-4143139-A | ANALGESICS, HYPOTENSIVES, IMMUNOSUPPRESSANTS, TRANQUILIZERS, ANTISECRETORY, ANTI-ANXIETY | PFIZER INC. (US) | 1979-03-06 | — | — | US | disclosed |