Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB2 known ✓ | P30411 | 6/20 | 0.43 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6251513 | 0.76 | HRH3 (0.38) | ALOX5 | |
| SCHEMBL11874825 | 0.74 | PI4KA (0.41) | — | |
| SCHEMBL3186205 | 0.73 | GPR84 (0.42) | ALOX5 | |
| SCHEMBL7680733 | 0.73 | GPR84 (0.42) | ALOX5 | |
| SCHEMBL24445917 | 0.71 | — | — | |
| Hydrochloric Acid SCHEMBL11380968 | 0.71 | ALOX5 (0.35) | BDKRB2DNM1ALOX5 | |
| Hydrochloric Acid SCHEMBL2972038 | 0.69 | BDKRB2 (0.35) | BDKRB2 | |
| Acetic Acid SCHEMBL21996138 | 0.68 | BRS3 (0.43) | — | |
| SCHEMBL22871224 | 0.67 | TSHR (0.42) | — | |
| Hydrochloric Acid SCHEMBL15065056 | 0.64 | ALDH1A1 (0.59) | BDKRB2DNM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4267337-A | Imidazolemethylphosphonium salts | SK&F LAB CO. (US) | 1981-05-12 | — | — | US | disclosed |
| US-4215217-A | Process for preparing 4-substituted imidazole compounds | SK&F LAB CO. (US) | 1980-07-29 | — | — | US | disclosed |
| US-4163858-A | Process for preparing new imidazolemethylphosphonium salts | SK&F LAB CO. (US) | 1979-08-07 | — | — | US | disclosed |
| US-4139708-A | Intermediates and processes useful for preparing medicinal agents imidazolemethylphosphonium salts | SK&F LAB CO. (US) | 1979-02-13 | — | — | US | disclosed |
| US-4119781-A | Process for preparing 4-substituted imidazole compounds | SK&F LAB CO. (US) | 1978-10-10 | — | — | US | disclosed |
| US-4104472-A | Imidazolemethylphosphonium salts | SMITHKLINE CORPORATION (US) | 1978-08-01 | — | — | US | disclosed |