Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CNR1 | P21554 | 9/20 | 0.32 |
| ▸ | CNR2 | P34972 | 9/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.32 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.32 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.32 |
| ▸ | TRPV5 | Q9NQA5 | 1/20 | 0.32 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.32 |
| ▸ | TRPV2 | Q9Y5S1 | 1/20 | 0.32 |
| ▸ | TNKS | O95271 | 1/20 | 0.32 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31545431 | 0.82 | CNR2 (0.51) | OPRM1CNR1CNR2TRPA1TRPM8 | |
| SCHEMBL11381891 | 0.82 | CNR1 (0.37) | OPRM1CNR1CNR2TRPA1HTR1A | |
| SCHEMBL11382147 | 0.74 | CYP19A1 (0.35) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL11384600 | 0.73 | KDR (0.32) | — | |
| SCHEMBL11375232 | 0.70 | RIPK1 (0.31) | CNR2 | |
| SCHEMBL11380256 | 0.68 | KDR (0.34) | CNR2 | |
| SCHEMBL11474154 | 0.68 | CNR2 (0.62) | CNR1CNR2 | |
| SCHEMBL11578289 | 0.68 | CNR2 (0.62) | CNR1CNR2 | |
| SCHEMBL11578292 | 0.68 | CNR2 (0.62) | CNR1CNR2 | |
| SCHEMBL11665838 | 0.67 | CNR2 (0.69) | OPRM1CNR1CNR2TRPA1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4133816-A | Preparation of cis-1-hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-ones and intermediates therefor | ELI LILLY AND COMPANY (US) | 1979-01-09 | — | — | US | disclosed |
| US-4088777-A | Hexahydro-dibenzo[b,d]pyran-9-ones as anticonvulsant drugs | ELI LILLY AND COMPANY (US) | 1978-05-09 | — | — | US | disclosed |
| US-4087547-A | Hexahydro-dibenzo[b,d]pyran-9-ones in treatment of glaucoma | ELI LILLY AND COMPANY (US) | 1978-05-02 | — | — | US | disclosed |
| US-4087546-A | Hexahydro-dibenzo[b,d]pyran-9-ones as antiasthmatic drugs | ELI LILLY AND COMPANY (US) | 1978-05-02 | — | — | US | disclosed |
| US-4087545-A | Hexahydro-dibenzo[b,d]pyran-9-ones as antiemetic drugs | ELI LILLY AND COMPANY (US) | 1978-05-02 | — | — | US | disclosed |
| US-4054581-A | Preparation of cis-1-hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-ones and intermediates therefor | ELI LILLY AND COMPANY (US) | 1977-10-18 | — | — | US | disclosed |
| US-4024275-A | Method of reducing elevated blood pressure with dihydroxy-hexahydrodibenzo(b,d)pyrans | ELI LILLY AND COMPANY (US) | 1977-05-17 | — | — | US | disclosed |
| US-3987188-A | Hexahydro-dibenzo[b,d]pyran-9-ones as sedative drugs | ELI LILLY AND COMPANY (US) | 1976-10-19 | — | — | US | disclosed |
| US-3968125-A | Dihydroxyhexahydrodibenzo[b,d]pyrans | ELI LILLY AND COMPANY (US) | 1976-07-06 | — | — | US | disclosed |
| US-3953603-A | Hexahydro-dibenzo[b,d,]pyran-9-ones as psychotropic, particularly anti-depressant drugs | ELI LILLY AND COMPANY (US) | 1976-04-27 | — | — | US | disclosed |
| US-3944673-A | Hexahydro-dibenzo[b,d]pyran-9-ones as analgesic drugs | ELI LILLY AND COMPANY (US) | 1976-03-16 | — | — | US | disclosed |