Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ORAI1 | Q96D31 | 3/20 | 0.57 |
| ▸ | ORAI2 | Q96SN7 | 3/20 | 0.57 |
| ▸ | ORAI3 | Q9BRQ5 | 3/20 | 0.57 |
| ▸ | TRPV6 | Q9H1D0 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31116653 | 0.82 | ALDH1A1 (0.69) | ALDH1A1ALOX15TDP1HSD17B10KDM4E | |
| SCHEMBL59751 | 0.82 | ALDH1A1 (0.69) | ALDH1A1ALOX15TDP1HSD17B10KDM4E | |
| SCHEMBL1138482 | 0.82 | TRPV6 (0.80) | ORAI1ORAI2ORAI3TRPV6ALOX15 | |
| Hydrochloric Acid SCHEMBL2876035 | 0.79 | ALDH1A1 (0.65) | ALDH1A1ALOX15TDP1HSD17B10KDM4E | |
| SCHEMBL8162988 | 0.79 | ALDH1A1 (0.65) | ALDH1A1ALOX15TDP1HSD17B10KDM4E | |
| SCHEMBL239719 | 0.75 | ENPP2 (0.67) | ORAI1ORAI2ORAI3TRPV6ALDH1A1 | |
| SCHEMBL9369 | 0.75 | ALDH1A1 (0.58) | ALDH1A1ALOX15TDP1HSD17B10HPGD | |
| SCHEMBL1138364 | 0.73 | ALDH1A1 (0.55) | ALDH1A1ALOX15TDP1HSD17B10HPGD | |
| Hydrochloric Acid SCHEMBL18641492 | 0.73 | TSHR (0.55) | ALDH1A1ALOX15TDP1HSD17B10HPGD | |
| SCHEMBL4833078 | 0.71 | TRPV6 (0.76) | ORAI1ORAI2ORAI3TRPV6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765358-B1 | TREATMENT OR PREVENTION OF SKIN CONDITIONS OR TISSUE CONDITIONS IN ANIMALS USING BORYLOXYPYRIDYLMETHANONES | ANACOR PHARMACEUTICALS INC (US) | 2011-02-23 | — | — | EP | disclosed |
| US-7652000-B2 | Boron-containing compounds and methods of use | ANACOR PHARMACEUTICALS, INC. (US) | 2010-01-26 | — | — | US | disclosed |
| EP-1765358-A2 | TREATMENT OR PREVENTION OF SKIN CONDITIONS OR TISSUE CONDITIONS IN ANIMALS USING BORYLOXYPYRIDYLMETHANONES | Anacor Pharmaceuticals, Inc. (US) | 2007-03-28 | — | — | EP | disclosed |
| US-20060009422-A1 | Boron-containing compounds and methods of use | ANACOR PHARMACEUTICALS, INC. | 2006-01-12 | — | — | US | disclosed |
| WO-2005123094-A2 | TREATMENT OR PREVENTION OF SKIN CONDITIONS OR TISSUE CONDITIONS IN ANIMALS USING BORYLOXYPYRIDYLMETHANONES | ANACOR PHARMACEUTICALS, INC. (US) | 2005-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060009422-A1 | Boron-containing compounds and methods of use | BROX, BTD, PBDC1 | ORAI1 2751/4885ORAI2 3905/4885ORAI3 3639/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.