Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 2/20 | 0.52 |
| ▸ | TRIM33 | Q9UPN9 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | GABRP | O00591 | 1/20 | 0.30 |
| ▸ | GABRD | O14764 | 1/20 | 0.30 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.30 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Morpholine SCHEMBL27350345 | 0.98 | GAA (0.52) | TRIM24TRIM33ALDH1A1GAAMEN1 | |
| Morpholine SCHEMBL4996263 | 0.85 | GAA (0.55) | TRIM24TRIM33GAAMEN1KMT2A | |
| Cyclohexylamine SCHEMBL10414047 | 0.85 | TRIM24 (0.38) | TRIM24TRIM33ALDH1A1GAAMEN1 | |
| Morpholine SCHEMBL8785153 | 0.84 | GAA (0.48) | TRIM24TRIM33ALDH1A1GAAMEN1 | |
| Cyclohexanone SCHEMBL8612676 | 0.82 | ALDH1A1 (0.69) | TRIM24TRIM33ALDH1A1GAACA1 | |
| Cycloheptanone SCHEMBL28108288 | 0.82 | ALDH1A1 (0.69) | TRIM24TRIM33ALDH1A1GAACA1 | |
| Cyclohexanone SCHEMBL5985420 | 0.82 | ALDH1A1 (0.69) | TRIM24TRIM33ALDH1A1GAACA1 | |
| SCHEMBL25196474 | 0.79 | ALDH1A1 (0.65) | TRIM24TRIM33ALDH1A1CA1CA9 | |
| SCHEMBL25194472 | 0.79 | ALDH1A1 (0.65) | TRIM24TRIM33ALDH1A1CA1CA9 | |
| SCHEMBL25198995 | 0.79 | ALDH1A1 (0.65) | TRIM24TRIM33ALDH1A1CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4257949-A | AMINATION | THE UPJOHN COMPANY (US) | 1981-03-24 | — | — | US | claimed |
| US-11375716-B2 | Acetyl-CoA carboxylase modulators | MONSANTO TECHNOLOGY LLC (US) | 2022-07-05 | — | — | US | disclosed |
| US-20200214289-A1 | ACETYL-COA CARBOXYLASE MODULATORS | MONSANTO TECHNOLOGY LLC (US) | 2020-07-09 | — | — | US | disclosed |
| US-10548313-B2 | Acetyl-CoA carboxylase modulators | MONSANTO TECHNOLOGY LLC (US) | 2020-02-04 | — | — | US | disclosed |
| US-20180070589-A1 | ACETYL-COA CARBOXYLASE MODULATORS | MONSANTO TECHNOLOGY LLC (US) | 2018-03-15 | — | — | US | disclosed |
| US-9844218-B2 | Acetyl-CoA carboxylase modulators | MONSANTO TECHNOLOGY LLC (US) | 2017-12-19 | — | — | US | disclosed |
| US-20160130229-A1 | ACETYL-COA CARBOXYLASE MODULATORS | MONSANTO TECHNOLOGY LLC (US) | 2016-05-12 | — | — | US | disclosed |
| WO-2014201326-A1 | ACETYL-COA CARBOXYLASE MODULATORS | MONSANTO TECHNOLOGY LLC (US) | 2014-12-18 | — | — | WO | disclosed |
| EP-1000023-B1 | NOVEL NITRIC OXIDE-RELEASING AMIDINE- AND ENAMINE-DERIVED DIAZENIUMDIOLATES, COMPOSITIONS AND USES THEREOF AND METHOD OF MAKING SAME | US GOV HEALTH & HUMAN SERV (US) | 2011-02-23 | — | — | EP | disclosed |
| US-6911478-B2 | Nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions and uses thereof and method of making same | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2005-06-28 | — | — | US | disclosed |
| US-20040180863-A1 | Novel, nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions and uses thereof and method of making same | GOVT. OF THE USA, REP. BY THE SECRETARY, DEPT. OF HEALTH & HUMAN SERVS., OFFICE OF TECH. TRANSFER | 2004-09-16 | — | — | US | disclosed |
| US-6750254-B2 | N2O2- FUNCTIONALITY IS BOUND DIRECT TO A CARBON ATOM; TREATING BIOLOGICAL DISORDERS HYPERTENSION, RESTENOSIS, IMPOTENCY, GENETIC DISORDERS OR INFECTIONS | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2004-06-15 | — | — | US | disclosed |
| US-20030166619-A1 | Novel nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions and uses thereof and method of making same | GOVERNMENT OF THE U.S.A., REPRESENTED BY THE SECRETARY OF DEPT. OF HEALTH AND HUMAN SERVICES (US) | 2003-09-04 | — | — | US | disclosed |
| US-6511991-B2 | Treating an amines with acetamidating agents to formacetamidine derivatives of the amine-containing compounds and treating the acetamidine derivatives with nitric oxide gas to form an amidine-derived diazeniumdiolate | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2003-01-28 | — | — | US | disclosed |
| US-20010025052-A1 | Novel nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions and uses thereof and method of making same | HRABIE JOSEPH A (US) | 2001-09-27 | — | — | US | disclosed |
| US-6232336-B1 | HYPOTENSIVE AGENTS; NEUROTRANSMISSION; CYTOTOXICITY | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2001-05-15 | — | — | US | disclosed |
| EP-1000023-A2 | NOVEL NITRIC OXIDE-RELEASING AMIDINE- AND ENAMINE-DERIVED DIAZENIUMDIOLATES, COMPOSITIONS AND USES THEREOF AND METHOD OF MAKING SAME | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE DEPARTMENT OF HEALTH & HUMAN SERVICES (US) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999001427-A2 | NOVEL NITRIC OXIDE-RELEASING AMIDINE- AND ENAMINE-DERIVED DIAZENIUMDIOLATES, COMPOSITIONS AND USES THEREOF AND METHOD OF MAKING SAME | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH (US) | 1999-01-14 | — | — | WO | disclosed |
| US-4257949-A | AMINATION | THE UPJOHN COMPANY (US) | 1981-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160130229-A1 | ACETYL-COA CARBOXYLASE MODULATORS | ACACA, ACACB, ACAT2 | TRIM24 1825/4885TRIM33 2519/4885ALDH1A1 1039/4885 |
| US-11375716-B2 | Acetyl-CoA carboxylase modulators | ACACA, ACACB, ACAT2 | TRIM24 1825/4885TRIM33 2519/4885ALDH1A1 1039/4885 |
| US-20030166619-A1 | Novel nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions and uses thereof and method of making same | NOS2, NOS1, NOS3 | TRIM24 4671/4885TRIM33 4676/4885ALDH1A1 3003/4885 |
| US-10548313-B2 | Acetyl-CoA carboxylase modulators | ACACA, ACACB, ACAT2 | TRIM24 1825/4885TRIM33 2519/4885ALDH1A1 1039/4885 |
| US-20040180863-A1 | Novel, nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions and uses thereof and method of making same | NOS2, NOS1, NOS3 | TRIM24 4705/4885TRIM33 4674/4885ALDH1A1 2899/4885 |
| US-20200214289-A1 | ACETYL-COA CARBOXYLASE MODULATORS | ACACA, ACACB, ACAT2 | TRIM24 1825/4885TRIM33 2519/4885ALDH1A1 1039/4885 |
| US-20010025052-A1 | Novel nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions and uses thereof and method of making same | NOS2, NOS1, NOS3 | TRIM24 4681/4885TRIM33 4663/4885ALDH1A1 2964/4885 |
| US-20180070589-A1 | ACETYL-COA CARBOXYLASE MODULATORS | ACACA, ACACB, ACAT2 | TRIM24 1825/4885TRIM33 2519/4885ALDH1A1 1039/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.