Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 3/20 | 0.32 |
| ▸ | CA2 | P00918 | 3/20 | 0.32 |
| ▸ | CA9 | Q16790 | 3/20 | 0.32 |
| ▸ | CA7 | P43166 | 2/20 | 0.32 |
| ▸ | CA12 | O43570 | 2/20 | 0.32 |
| ▸ | CA5A | P35218 | 1/20 | 0.32 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.32 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.31 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4106449 | 0.84 | HTT (0.47) | PNMTALDH1A1MEN1LMNAMAPT | |
| SCHEMBL140625 | 0.78 | PSIP1 (0.54) | PNMTALDH1A1MEN1LMNAMAPT | |
| Benzene SCHEMBL28057885 | 0.78 | PSIP1 (0.54) | PNMTALDH1A1MEN1LMNAMAPT | |
| SCHEMBL7780440 | 0.77 | PNMT (0.37) | PNMTALDH1A1MEN1LMNAMAPT | |
| Ethylene SCHEMBL27737865 | 0.77 | PSIP1 (0.52) | PNMTALDH1A1MEN1LMNAMAPT | |
| SCHEMBL27851864 | 0.76 | CTSK (0.37) | CTSK | |
| SCHEMBL2148798 | 0.75 | GAA (0.55) | PNMTALDH1A1MEN1LMNAKMT2A | |
| SCHEMBL10524502 | 0.75 | CA2 (0.52) | PNMTALDH1A1MEN1LMNAMAPT | |
| SCHEMBL3626870 | 0.75 | CTSK (0.59) | PNMTALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL13183908 | 0.75 | PLCG1 (0.59) | PNMTALDH1A1MEN1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 730 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230322816-A1 | PYRAZOLE BORONIC ACID COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USES THEREOF | BEIJING SONGRUN PHARMACEUTICAL TECHNOLOGY CO., LTD. (CN) | 2023-10-12 | — | — | US | claimed |
| CN-116685325-A | Combination therapy of a PD-1 axis binding antagonist and an LRRK2 inhibitor | 豪夫迈·罗氏有限公司 | 2023-09-01 | — | — | CN | claimed |
| EP-4232040-A1 | COMBINATION THERAPY OF PD-1 AXIS BINDING ANTAGONISTS AND LRRK2 INHITIBORS | F. Hoffmann-La Roche AG (CH) | 2023-08-30 | — | — | EP | claimed |
| EP-4201941-A1 | PYRAZOLE BORONIC ACID COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USES THEREOF | Beijing Songrun Pharmaceutical Technology Co., Ltd. (CN) | 2023-06-28 | — | — | EP | claimed |
| WO-2022084210-A1 | COMBINATION THERAPY OF PD-1 AXIS BINDING ANTAGONISTS AND LRRK2 INHITIBORS | F. HOFFMANN-LA ROCHE AG (CH) | 2022-04-28 | — | — | WO | claimed |
| EP-3943497-A1 | TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES AS CB2 RECEPTOR ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2022-01-26 | — | — | EP | claimed |
| EP-3483163-B1 | TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES AS CB2 RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2021-06-23 | — | — | EP | claimed |
| EP-3172264-B1 | NOVEL POLYMERS CONTAINING GRAFTED BIS(SULFONYL)IMIDE SODIUM OR LITHIUM SALTS TO THE METHODS FOR THE PRODUCTION THEREOF, AND TO THE USES OF SAME AS ELECTROLYTES FOR BATTERIES | CDP INNOVATION (FR) | 2021-06-16 | — | — | EP | claimed |
| EP-3172259-B1 | NOVEL POLYMERS CONTAINING SULPHONAMIDE SODIUM OR LITHIUM SALTS, PRODUCTION METHODS THEREOF AND USES OF SAME AS ELECTROLYTES FOR BATTERIES | CDP INNOVATION (FR) | 2021-05-19 | — | — | EP | claimed |
| CN-107001622-B | Novel polymers containing grafted sodium or lithium bis (sulfonyl) imide salts, method for the production thereof and use thereof as battery electrolytes | CDP创新公司 | 2020-01-07 | — | — | CN | claimed |
| US-4400395-A | ANTI-ARTHRITIC,-CARCINOGENIC,-SEROTONIN,-HISTAMINE AGENTS; HYPOTENSIVES | MERCK & CO., INC. (US) | 1983-08-23 | — | — | US | claimed |
| US-4332813-A | Allylsulfoxide enzyme inhibitors | MERCK & CO., INC. (US) | 1982-06-01 | — | — | US | claimed |
| US-4293306-A | Process for the dyeing and printing of hydrophobic synthetic organic fiber materials with water-insoluble azo dyestuffs | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-10-06 | — | — | US | claimed |
| EP-0024639-A1 | Organic sulfoxides having a latent allyl group, process for preparing the same and pharmaceutical enzyme inhibiting composition comprising the same | MERCK & CO. INC. (US) | 1981-03-11 | — | — | EP | claimed |
| US-4166827-A | DENTAL PLAQUE | COOPER LABORATORIES, INC. (US) | 1979-09-04 | — | — | US | claimed |
| US-4118232-A | Photographic material containing sulphonic acid group containing disazo dyestuffs | CIBA-GEIGY AG (CH) | 1978-10-03 | — | — | US | claimed |
| US-4115448-A | Carbamylguanidine antimicrobial compounds | COOPER LABORATORIES, INC. (US) | 1978-09-19 | — | — | US | claimed |
| US-4110328-A | Bis-carbamylguanidinoazaalkane antimicrobial compounds | COOPER LABORATORIES, INC. (US) | 1978-08-29 | — | — | US | claimed |
| US-4057642-A | ANTIINFLAMMATORY, RHEUMATOID ARTHRITIS | MERCK & CO., INC. (US) | 1977-11-08 | — | — | US | claimed |
| US-4022962-A | DENTAL PLAQUE INHIBITORS | COOPER LABORATORIES, INC. (US) | 1977-05-10 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230322816-A1 | PYRAZOLE BORONIC ACID COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USES THEREOF | PSMB11, PSMB7, PSMC5 | PNMT 4615/4885ALDH1A1 2816/4885MEN1 1052/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.