SCHEMBL11428693

SCHEMBL11428693

Cc1ccc(Oc2c(Cl)cccc2Cl)cc1

nearest known ligand 0.45

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TEAD4 Q15561 1/20 0.45
POLB P06746 2/20 0.43
MAPT P10636 2/20 0.43
TDP1 Q9NUW8 2/20 0.43
ALDH1A1 P00352 1/20 0.43
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
NPBWR1 P48145 7/20 0.42
MCHR1 Q99705 6/20 0.42
NPSR1 Q6W5P4 2/20 0.42
ACHE P22303 3/20 0.41
HTT P42858 2/20 0.40
BCHE P06276 2/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
L3MBTL1 Q9Y468 2/20 0.40
LMNA P02545 1/20 0.40
HPGD P15428 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13749241 0.80 MAPT (0.67) POLBMAPTTDP1ALDH1A1NPSR1
SCHEMBL9645022 0.79 LTA4H (0.52) POLBMAPTTDP1ALDH1A1MEN1
SCHEMBL11429293 0.79 ACHE (0.52) MAPTTDP1ALDH1A1MEN1KMT2A
SCHEMBL23061547 0.78 MAOA (0.56) TEAD4POLBMAPTTDP1ALDH1A1
SCHEMBL5544007 0.78 MAPT (0.41) POLBMAPTKMT2AACHEBCHE
SCHEMBL3874015 0.78 TEAD4 (0.59) TEAD4POLBMAPTTDP1ALDH1A1
Nitrogen SCHEMBL23671381 0.78 BCHE (0.50) POLBMAPTKMT2ANPBWR1MCHR1
SCHEMBL11423806 0.78 TEAD4 (0.41) TEAD4POLBMAPTTDP1ALDH1A1
SCHEMBL5023569 0.77 SLC6A4 (0.51) TEAD4MAPTTDP1ALDH1A1HTT
SCHEMBL28246447 0.75 CYP1A2 (0.47) TDP1ALDH1A1MEN1KMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4203145-A Chloro-diphenyl BAYER AKTIENGESELLSCHAFT (DE) 1980-05-13 US disclosed