Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG | P00747 | 4/20 | 0.42 |
| ▸ | KLK1 | P06870 | 3/20 | 0.42 |
| ▸ | KLK6 | Q92876 | 2/20 | 0.42 |
| ▸ | FADS1 | O60427 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 3/20 | 0.41 |
| ▸ | F2 | P00734 | 2/20 | 0.41 |
| ▸ | F10 | P00742 | 2/20 | 0.41 |
| ▸ | PLAT | P00750 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.40 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11440791 | 0.91 | PLG (0.45) | PLGKLK1KLK6CYP1A2AURKA | |
| SCHEMBL11428140 | 0.87 | PLAU (0.46) | PLGKLK1KLK6FADS1CYP1A2 | |
| SCHEMBL11425192 | 0.85 | KCNMA1 (0.44) | MEN1POLBKMT2ANPC1RAB9A | |
| SCHEMBL11432224 | 0.83 | KCNMA1 (0.47) | PLGKLK1KLK6MEN1POLB | |
| SCHEMBL11439444 | 0.83 | TTR (0.43) | PLGKLK1KLK6FADS1CYP1A2 | |
| SCHEMBL11438773 | 0.83 | CASP6 (0.43) | CYP1A2AURKAAURKBMEN1KMT2A | |
| SCHEMBL11438825 | 0.82 | MEN1 (0.41) | AURKAAURKBPLAUF2F10 | |
| SCHEMBL11435261 | 0.80 | AURKA (0.44) | PLGKLK1KLK6FADS1AURKA | |
| SCHEMBL11426487 | 0.80 | AURKA (0.44) | AURKAAURKBMEN1KMT2ANPC1 | |
| SCHEMBL11435464 | 0.80 | NT5E (0.50) | PLGKLK1CYP1A2PLAUF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4216165-A | Amine precursors to ureide inhibitors of connective tissue destruction | AMERICAN CYANAMID COMPANY (US) | 1980-08-05 | — | — | US | disclosed |