Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.61 |
| ▸ | HTR7 | P34969 | 6/20 | 0.61 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11465556 | 0.93 | HTR1A (0.58) | HTR1AHTR7DRD2HTR2AHTR6 | |
| Methane SCHEMBL11605143 | 0.92 | HTR1A (0.57) | HTR1AHTR7DRD2HTR2AHTR6 | |
| SCHEMBL11446583 | 0.90 | HTR7 (0.63) | HTR1AHTR7DRD2HTR2AHTR6 | |
| SCHEMBL11454722 | 0.90 | HTR7 (0.74) | HTR1AHTR7DRD2HTR2AHTR6 | |
| SCHEMBL11446686 | 0.90 | HTR7 (0.64) | HTR1AHTR7DRD2HTR2AHTR6 | |
| SCHEMBL11454884 | 0.89 | HTR1A (0.59) | HTR1AHTR7DRD2HTR2A | |
| SCHEMBL11465485 | 0.89 | HTR7 (0.54) | HTR1AHTR7DRD2HTR2AHTR6 | |
| SCHEMBL11454249 | 0.89 | HTR1A (0.70) | HTR1AHTR7HTR2ACACNA1G | |
| SCHEMBL11446221 | 0.87 | HTR7 (0.61) | HTR1AHTR7DRD2HTR2AHTR6 | |
| SCHEMBL11447385 | 0.87 | HTR7 (0.61) | HTR1AHTR7DRD2HTR2AHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4205173-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1980-05-27 | — | — | US | disclosed |
| US-4085107-A | ANALGESICS | PENNWALT CORPORATION (US) | 1978-04-18 | — | — | US | disclosed |
| US-4060526-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1977-11-29 | — | — | US | disclosed |