Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 10/20 | 0.59 |
| ▸ | HTR7 | P34969 | 3/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.56 |
| ▸ | HTR2A | P28223 | 4/20 | 0.56 |
| ▸ | DRD2 | P14416 | 4/20 | 0.56 |
| ▸ | HRH1 | P35367 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 4/20 | 0.53 |
| ▸ | HTR2C | P28335 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11447580 | 0.94 | HTR1A (0.56) | HTR1AHTR7KCNH2HTR2ADRD2 | |
| SCHEMBL11446577 | 0.89 | HTR1A (0.61) | HTR1AHTR7HTR2ADRD2 | |
| SCHEMBL11454249 | 0.89 | HTR1A (0.70) | HTR1AHTR7KCNH2HTR2ADRD3 | |
| SCHEMBL11454722 | 0.88 | HTR7 (0.74) | HTR1AHTR7KCNH2HTR2ADRD2 | |
| SCHEMBL11446583 | 0.88 | HTR7 (0.63) | HTR1AHTR7HTR2ADRD2DRD3 | |
| SCHEMBL11446335 | 0.88 | HTR7 (0.53) | HTR1AHTR7 | |
| SCHEMBL11446686 | 0.88 | HTR7 (0.64) | HTR1AHTR7KCNH2HTR2ADRD2 | |
| SCHEMBL11447937 | 0.86 | HTR7 (0.60) | HTR1AHTR7KCNH2DRD2DRD3 | |
| SCHEMBL11465175 | 0.86 | HTR7 (0.60) | HTR1AHTR7KCNH2DRD2DRD3 | |
| SCHEMBL11446702 | 0.83 | HTR1A (0.67) | HTR1AHTR7KCNH2HTR2ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4205173-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1980-05-27 | — | — | US | disclosed |
| US-4085107-A | ANALGESICS | PENNWALT CORPORATION (US) | 1978-04-18 | — | — | US | disclosed |
| US-4060526-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1977-11-29 | — | — | US | disclosed |