Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 8/20 | 0.63 |
| ▸ | HTR1A | P08908 | 8/20 | 0.63 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 3/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11456939 | 0.94 | HTR1A (0.59) | HTR7HTR1AOPRM1DRD2ADRA1A | |
| SCHEMBL11446577 | 0.90 | HTR1A (0.61) | HTR7HTR1ADRD2HTR2AHTR6 | |
| SCHEMBL11454722 | 0.89 | HTR7 (0.74) | HTR7HTR1ADRD2ADRA1ADRD3 | |
| SCHEMBL11446686 | 0.89 | HTR7 (0.64) | HTR7HTR1ADRD2DRD3HTR2A | |
| SCHEMBL11454884 | 0.88 | HTR1A (0.59) | HTR7HTR1ADRD2DRD3HTR2A | |
| SCHEMBL11465875 | 0.88 | HTR7 (0.55) | HTR7HTR1ADRD3HTR2A | |
| SCHEMBL11454249 | 0.88 | HTR1A (0.70) | HTR7HTR1ADRD3HTR2ACACNA1G | |
| SCHEMBL11446043 | 0.87 | HTR7 (0.62) | HTR7HTR1ADRD2DRD3HTR2A | |
| SCHEMBL11447049 | 0.86 | HTR7 (0.61) | HTR7HTR1ADRD2DRD3 | |
| SCHEMBL11465485 | 0.84 | HTR7 (0.54) | HTR7HTR1ADRD2HTR2AHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4205173-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1980-05-27 | — | — | US | disclosed |
| US-4085107-A | ANALGESICS | PENNWALT CORPORATION (US) | 1978-04-18 | — | — | US | disclosed |
| US-4060526-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1977-11-29 | — | — | US | disclosed |