Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 4/20 | 0.74 |
| ▸ | HTR1A | P08908 | 4/20 | 0.74 |
| ▸ | DRD2 | P14416 | 4/20 | 0.63 |
| ▸ | HTR2A | P28223 | 3/20 | 0.63 |
| ▸ | HTR6 | P50406 | 2/20 | 0.63 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | DRD4 | P21917 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11456938 | 0.94 | HTR1A (0.71) | HTR7HTR1ADRD2HTR2AHTR6 | |
| SCHEMBL11446577 | 0.90 | HTR1A (0.61) | HTR7HTR1ADRD2HTR2AHTR6 | |
| SCHEMBL11446583 | 0.89 | HTR7 (0.63) | HTR7HTR1ADRD2HTR2AHTR6 | |
| SCHEMBL11447175 | 0.89 | HTR7 (0.59) | HTR7HTR1ADRD2CACNA1GTP53 | |
| SCHEMBL11446686 | 0.89 | HTR7 (0.64) | HTR7HTR1ADRD2HTR2AHTR6 | |
| SCHEMBL11454884 | 0.88 | HTR1A (0.59) | HTR7HTR1ADRD2HTR2AKCNH2 | |
| SCHEMBL11454249 | 0.88 | HTR1A (0.70) | HTR7HTR1AHTR2ACACNA1GKCNH2 | |
| SCHEMBL11447592 | 0.87 | HTR7 (0.60) | HTR7HTR1ADRD2HTR2AHTR6 | |
| SCHEMBL11447942 | 0.87 | HTR7 (0.60) | HTR7HTR1ADRD2HTR2AHTR6 | |
| SCHEMBL11465485 | 0.84 | HTR7 (0.54) | HTR7HTR1ADRD2HTR2AHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4205173-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1980-05-27 | — | — | US | disclosed |
| US-4085107-A | ANALGESICS | PENNWALT CORPORATION (US) | 1978-04-18 | — | — | US | disclosed |