Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11447323 | 0.87 | ALDH1A1 (0.41) | KMT2AALDH1A1SMN1; SMN2MEN1GAA | |
| SCHEMBL11446712 | 0.86 | DRD3 (0.50) | — | |
| SCHEMBL11446241 | 0.85 | GAA (0.46) | KMT2AALDH1A1KDM4EMEN1GAA | |
| SCHEMBL11455011 | 0.82 | DRD4 (0.58) | MAPTTP53 | |
| SCHEMBL11497813 | 0.81 | ALDH1A1 (0.55) | KMT2AALDH1A1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL11454487 | 0.79 | MEN1 (0.48) | KMT2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL11446412 | 0.77 | HTR1A (0.59) | KMT2AALDH1A1KDM4EMAPTTP53 | |
| SCHEMBL11466052 | 0.75 | OPRM1 (0.43) | KDM4E | |
| SCHEMBL5262043 | 0.74 | ALDH1A1 (0.45) | KMT2AALDH1A1RECQLSMN1; SMN2KDM4E | |
| SCHEMBL11446001 | 0.73 | GFER (0.61) | KMT2ARECQLMEN1MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4205173-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1980-05-27 | — | — | US | disclosed |
| US-4060526-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1977-11-29 | — | — | US | disclosed |