Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.45 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.45 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.45 |
| ▸ | CCR1 | P32246 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
| ▸ | CCR3 | P51677 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11446630 | 0.88 | DRD2 (0.46) | MEN1KMT2AALDH1A1DRD2CCR1 | |
| SCHEMBL11456856 | 0.86 | DRD2 (0.46) | MEN1KMT2AALDH1A1DRD2DRD3 | |
| SCHEMBL11466052 | 0.85 | OPRM1 (0.43) | DRD2DRD3OPRM1OPRD1OPRK1 | |
| SCHEMBL11446528 | 0.84 | DRD2 (0.50) | MEN1KMT2ADRD2CCR1OPRM1 | |
| SCHEMBL11455011 | 0.83 | DRD4 (0.58) | DRD2DRD3 | |
| SCHEMBL11446712 | 0.81 | DRD3 (0.50) | DRD2DRD3OPRM1 | |
| SCHEMBL11446735 | 0.79 | KMT2A (0.49) | MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL11446412 | 0.78 | HTR1A (0.59) | KMT2AALDH1A1LMNADRD2 | |
| SCHEMBL11455002 | 0.76 | OPRM1 (0.42) | DRD3OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL11465441 | 0.75 | ADRA1A (0.42) | ALDH1A1DRD2DRD3OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4205173-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1980-05-27 | — | — | US | disclosed |
| US-4085107-A | ANALGESICS | PENNWALT CORPORATION (US) | 1978-04-18 | — | — | US | disclosed |
| US-4060526-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1977-11-29 | — | — | US | disclosed |