Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 6/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.44 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11455144 | 0.91 | OPRD1 (0.43) | OPRM1OPRK1OPRD1OPRL1CCR1 | |
| SCHEMBL11465183 | 0.90 | OPRD1 (0.43) | OPRM1OPRK1OPRD1OPRL1DRD3 | |
| SCHEMBL11604012 | 0.89 | OPRM1 (0.47) | OPRM1OPRK1OPRD1OPRL1DRD3 | |
| SCHEMBL11466052 | 0.84 | OPRM1 (0.43) | OPRM1OPRK1OPRD1OPRL1SOAT1 | |
| SCHEMBL11446372 | 0.81 | OPRK1 (0.44) | OPRM1OPRK1OPRD1OPRL1DRD3 | |
| SCHEMBL11454733 | 0.79 | ADRA1D (0.53) | HTR1AMAPTL3MBTL1MAPK1MEN1 | |
| SCHEMBL11457668 | 0.76 | ABCB1 (0.39) | OPRM1OPRK1OPRD1DRD2DRD3 | |
| SCHEMBL11455002 | 0.76 | OPRM1 (0.42) | OPRM1OPRK1OPRD1OPRL1DRD3 | |
| SCHEMBL11446845 | 0.74 | OPRM1 (0.42) | OPRM1OPRK1OPRD1OPRL1DRD3 | |
| SCHEMBL11446709 | 0.72 | GFER (0.54) | HTR1AMAPTL3MBTL1MAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4205173-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1980-05-27 | — | — | US | disclosed |
| US-4085107-A | ANALGESICS | PENNWALT CORPORATION (US) | 1978-04-18 | — | — | US | disclosed |
| US-4060526-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1977-11-29 | — | — | US | disclosed |