Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 12/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 10/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.34 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11447955 | 0.91 | OPRM1 (0.44) | OPRD1OPRK1OPRM1OPRL1CCR1 | |
| SCHEMBL11465183 | 0.91 | OPRD1 (0.43) | OPRD1OPRK1OPRM1OPRL1ABCB1 | |
| SCHEMBL11604012 | 0.90 | OPRM1 (0.47) | OPRD1OPRK1OPRM1OPRL1ABCB1 | |
| SCHEMBL11455002 | 0.84 | OPRM1 (0.42) | OPRD1OPRK1OPRM1OPRL1DRD3 | |
| SCHEMBL11446372 | 0.82 | OPRK1 (0.44) | OPRD1OPRK1OPRM1OPRL1DRD3 | |
| SCHEMBL11446875 | 0.77 | ADRA1D (0.52) | — | |
| SCHEMBL11457668 | 0.77 | ABCB1 (0.39) | OPRD1OPRK1OPRM1ABCB1DRD3 | |
| SCHEMBL11466052 | 0.75 | OPRM1 (0.43) | OPRD1OPRK1OPRM1OPRL1DRD3 | |
| SCHEMBL11446845 | 0.75 | OPRM1 (0.42) | OPRD1OPRK1OPRM1OPRL1DRD3 | |
| SCHEMBL11447147 | 0.73 | OPRM1 (0.46) | OPRD1OPRK1OPRM1OPRL1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4205173-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1980-05-27 | — | — | US | disclosed |
| US-4085107-A | ANALGESICS | PENNWALT CORPORATION (US) | 1978-04-18 | — | — | US | disclosed |
| US-4060526-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1977-11-29 | — | — | US | disclosed |