SCHEMBL114535

SCHEMBL114535

O=C(Cl)c1cc(C(F)(F)F)nn1-c1ncccc1Cl

nearest known ligand 0.49

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
MEN1 O00255 1/20 0.46
ALDH1A1 P00352 1/20 0.46
MAPT P10636 1/20 0.46
KMT2A Q03164 1/20 0.46
TRPV1 Q8NER1 7/20 0.40
TRPA1 O75762 2/20 0.40
KLKB1 P03952 2/20 0.39
GPBAR1 Q8TDU6 1/20 0.38
PTGS1 P23219 1/20 0.37
PTGS2 P35354 1/20 0.37
OPRL1 P41146 1/20 0.37
HSD11B1 P28845 1/20 0.36
MALT1 Q9UDY8 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30863652 1.00 KDM4E (0.49) KDM4EL3MBTL1MEN1ALDH1A1MAPT
SCHEMBL535347 0.90 KLKB1 (0.49) KDM4EL3MBTL1MEN1ALDH1A1MAPT
Hydrochloric Acid SCHEMBL536232 0.89 KLKB1 (0.48) KDM4EL3MBTL1MEN1ALDH1A1MAPT
SCHEMBL29488448 0.89 KDM4E (0.48) KDM4EL3MBTL1MEN1ALDH1A1MAPT
SCHEMBL354326 0.89 KDM4E (0.45) KDM4EL3MBTL1MEN1ALDH1A1MAPT
SCHEMBL15272015 0.89 KDM4E (0.48) KDM4EL3MBTL1MEN1ALDH1A1MAPT
SCHEMBL14698214 0.87 KDM4E (0.49) KDM4EL3MBTL1MEN1ALDH1A1MAPT
SCHEMBL28931331 0.87 GRN (0.46) KDM4ETRPV1TRPA1
SCHEMBL385572 0.83 KDM4E (0.44) KDM4EL3MBTL1MEN1ALDH1A1MAPT
SCHEMBL1680138 0.83 ALDH1A1 (0.44) KDM4EL3MBTL1MEN1ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 130 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113896712-B Diamide compound containing cyclic amino acid 华东理工大学 2024-04-09 CN disclosed
CN-113896712-A Diamide compound containing cyclic amino acid 华东理工大学 2022-01-07 CN disclosed
EP-2855474-B1 N-THIO-ANTHRANILAMIDE COMPOUNDS AND THEIR USE AS PESTICIDES BASF SE (DE) 2017-10-18 EP disclosed
CN-104487439-B N-thio-anthranilamide compounds and their use as pesticides 巴斯夫欧洲公司 2017-06-09 CN disclosed
CN-103842336-B Aniline type compound 巴斯夫欧洲公司 2017-05-31 CN disclosed
CN-103958496-B Process for preparing N-substituted 1H-pyrazole-5-formate compounds and derivatives thereof 巴斯夫欧洲公司 2017-05-24 CN disclosed
EP-1926728-B1 OXADIAZINE-SUBSTITUTED ARYLAMIDES BAYER IP GMBH (DE) 2017-04-05 EP disclosed
EP-1926728-B1 OXADIAZINE-SUBSTITUTED ARYLAMIDES BAYER IP GMBH (DE) 2017-04-05 EP disclosed
US-9556141-B2 Process for preparing N-substituted 1H-pyrazole-5-carboxylate compounds and derivatives thereof BASF SE (DE) 2017-01-31 US disclosed
US-9533968-B2 N-thio-anthranilamide compounds and their use as pesticides BASF SE (DE) 2017-01-03 US disclosed
WO-2008064891-A1 N-CYANOALKYLANTHRANILAMIDES AS INSECTICIDES SYNGENTA PARTICIPATIONS AG (CH) 2008-06-05 WO disclosed
US-20070203201-A1 Substituted anthranilamides for controlling invertebrate pests FINKELSTEIN BRUCE L 2007-08-30 US disclosed
WO-2007043677-A9 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2007-06-07 WO disclosed
WO-2007043677-A9 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2007-06-07 WO disclosed
WO-2007043677-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-04-19 WO disclosed
WO-2007043677-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-04-19 WO disclosed
US-7199138-B2 Substituted anthranilamides for controlling invertebrate pests E. I. DU PONT DE NEMOURS AND COMPANY (US) 2007-04-03 US disclosed
WO-2007031213-A1 DIOXAZINE- AND OXADIAZINE-SUBSTITUTED ARYLAMIDES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2007-03-22 WO disclosed
US-20050282868-A1 Substituted anthranilamides for controlling invertebrate pests E. I. DU PONT DE NEMOURS AND COMPANY 2005-12-22 US disclosed
CN-1653051-A Substituted anthranilamides for controlling invertebrate pests DU PONT (US) 2005-08-10 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070203201-A1 Substituted anthranilamides for controlling invertebrate pests ANTXR2, PRXL2A, F9 KDM4E 794/4885L3MBTL1 664/4885MEN1 3493/4885
US-20050282868-A1 Substituted anthranilamides for controlling invertebrate pests ANTXR2, PRXL2A, F9 KDM4E 834/4885L3MBTL1 654/4885MEN1 3214/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.