Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB2 | P30411 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.42 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.42 |
| ▸ | ITGAV | P06756 | 3/20 | 0.42 |
| ▸ | ITGA5 | P08648 | 3/20 | 0.42 |
| ▸ | ITGB5 | P18084 | 3/20 | 0.42 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP7 | P09237 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | NAAA | Q02083 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL116032 | 0.89 | BDKRB2 (0.47) | BDKRB2ALDH1A1NPSR1TP53ABCB1 | |
| SCHEMBL116901 | 0.87 | BDKRB2 (0.46) | BDKRB2ALDH1A1NPSR1TP53ABCB1 | |
| SCHEMBL115938 | 0.86 | ABCB1 (0.45) | BDKRB2ALDH1A1NPSR1TP53ABCB1 | |
| SCHEMBL3400542 | 0.86 | ABCB1 (0.45) | BDKRB2ALDH1A1NPSR1TP53ABCB1 | |
| SCHEMBL178628 | 0.85 | ABCB1 (0.44) | BDKRB2ALDH1A1NPSR1TP53ABCB1 | |
| SCHEMBL116041 | 0.83 | AGTR2 (0.48) | BDKRB2ALDH1A1NPSR1TP53P2RX4 | |
| SCHEMBL116053 | 0.82 | ALDH1A1 (0.46) | BDKRB2ALDH1A1NPSR1TP53PARP1 | |
| SCHEMBL3398953 | 0.82 | ALDH1A1 (0.46) | BDKRB2ALDH1A1NPSR1TP53PARP1 | |
| SCHEMBL115758 | 0.81 | ALDH1A1 (0.44) | BDKRB2ALDH1A1NPSR1TP53P2RX4 | |
| SCHEMBL3402980 | 0.81 | ALDH1A1 (0.44) | BDKRB2ALDH1A1NPSR1TP53P2RX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120058989-A1 | ANTIBACTERIAL FLUOROQUINOLONE ANALOGS | ACHAOGEN, INC. (US) | 2012-03-08 | — | — | US | disclosed |
| US-20120058989-A1 | ANTIBACTERIAL FLUOROQUINOLONE ANALOGS | ACHAOGEN, INC. (US) | 2012-03-08 | — | — | US | disclosed |
| US-20120058989-A1 | ANTIBACTERIAL FLUOROQUINOLONE ANALOGS | ACHAOGEN, INC. (US) | 2012-03-08 | — | — | US | disclosed |
| WO-2009137130-A2 | ANTIBACTERIAL FLUOROQUINOLONE ANALOGS | ACHAOGEN, INC. (US) | 2009-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058989-A1 | ANTIBACTERIAL FLUOROQUINOLONE ANALOGS | RECQL, BLVRB, NQO2 | BDKRB2 677/4885ALDH1A1 1678/4885NPSR1 2407/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.