Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 3/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.41 |
| ▸ | TDO2 | P48775 | 2/20 | 0.41 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19576827 | 1.00 | ADRB2 (0.56) | ADRB2TSHRMAPK1HIF1ATDP1 | |
| SCHEMBL332099 | 0.85 | ESR1 (0.38) | ADRB2LMNA | |
| SCHEMBL9643649 | 0.82 | TYR (0.46) | ADRB2MAPK1HIF1ALMNATP53 | |
| SCHEMBL197810 | 0.79 | ADRB2 (0.65) | ADRB2TSHRMAPK1HIF1ATDP1 | |
| SCHEMBL30720007 | 0.77 | ADRB2 (0.62) | ADRB2TSHRMAPK1HIF1ATDP1 | |
| SCHEMBL153358 | 0.77 | ADRB2 (0.62) | ADRB2TSHRMAPK1HIF1ATDP1 | |
| Hydrochloric Acid SCHEMBL28767407 | 0.77 | ADRB2 (0.62) | ADRB2TSHRMAPK1HIF1ATDP1 | |
| SCHEMBL9344523 | 0.77 | CYP19A1 (0.33) | ADRB2TSHRMAPK1TDP1CYP19A1 | |
| SCHEMBL4445207 | 0.77 | ADRB2 (0.62) | ADRB2TSHRMAPK1HIF1ATDP1 | |
| SCHEMBL6074846 | 0.77 | IDO1 (0.50) | ADRB2TSHRMAPK1HIF1ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023164236-A1 | COMPOUNDS AND METHODS USEFUL FOR STABILIZING PHENYLALANINE HYDROXYLASE MUTATIONS | AGIOS PHARMACEUTICALS, INC. (US) | 2023-08-31 | — | — | WO | disclosed |
| US-20230140941-A1 | NON-ATP/CATALYTIC SITE P38 MITOGEN ACTIVATED PROTEIN KINASE INHIBITORS | THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS | 2023-05-11 | — | — | US | disclosed |
| US-11530197-B2 | Analogs for the treatment of disease | INSILICO MEDICINE IP LIMITED (HK) | 2022-12-20 | — | — | US | disclosed |
| US-11530199-B2 | Analogs for the treatment of disease | INSILICO MEDICINE IP LIMITED (HK) | 2022-12-20 | — | — | US | disclosed |
| WO-2022123530-A1 | BORONIC ACID COMPOUND | 주식회사 엘지화학 | 2022-06-16 | — | — | WO | disclosed |
| EP-1964893-B2 | Ink composition, inkjet recording method, printed material, and ink set | FUJIFILM CORP (JP) | 2021-11-24 | — | — | EP | disclosed |
| US-20210230160-A1 | PHOSPHODIESTERASE INHIBITORS | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA | 2021-07-29 | — | — | US | disclosed |
| US-10961231-B2 | NTCP inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-03-30 | — | — | US | disclosed |
| US-20210040072-A1 | NTCP Inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-02-11 | — | — | US | disclosed |
| US-10399933-B2 | Inhibitors of indoleamine-2,3-dioxygenase for the treatment of cancer | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-09-03 | — | — | US | disclosed |
| US-7435844-B2 | Analogous compounds of strobilurines and their use as acaricides and insecticides | ISAGRO RICERCA S.R.L. (IT) | 2008-10-14 | — | — | US | disclosed |
| EP-1840176-A1 | Ink composition, inkjet recording method, printed material, and process for producing lithographic printing plate | FUJIFILM Corporation (JP) | 2007-10-03 | — | — | EP | disclosed |
| EP-1795564-A1 | Ink composition, inkjet recording method, production method of planographic printing plate, and planographic printing plate | Fujifilm Corporation (JP) | 2007-06-13 | — | — | EP | disclosed |
| US-20060235075-A1 | Analogous compounds of strobilurines and their use as acaricides and insecticides | ISAGRO RICERCA S.R.L. (IT) | 2006-10-19 | — | — | US | disclosed |
| WO-2006083673-A2 | PYRIDINE DERIVATIVES USEFUL AS INHIBITORS OF C-JUN N-TERMINAL KINASES | ABBOTT LABORATORIES (US) | 2006-08-10 | — | — | WO | disclosed |
| US-20060173050-A1 | Inhibitors of c-Jun N-terminal kinases | ABBVIE INC. | 2006-08-03 | — | — | US | disclosed |
| US-20050171132-A1 | Diaminopyrimidine derivatives as selective growth hormone secrectgogue receptor (GHS-R) antagonists | XIN ZHILI (US) | 2005-08-04 | — | — | US | disclosed |
| US-20050171131-A1 | Diaminopyrimidine derivatives as growth hormone secrectgogue receptor (GHS-R) antagonists | KOSOGOF CHRISTI (US) | 2005-08-04 | — | — | US | disclosed |
| WO-2005030734-A1 | DIAMINOPYRIMIDINE DERIVATIVES AS SELECTIVE GROWTH HORMONE SECRECTGOGUE RECEPTOR (GHS-R) ANTAGONISTS | ABBOTT LABORATORIES (US) | 2005-04-07 | — | — | WO | disclosed |
| US-20050070712-A1 | Pyrimidine derivatives as ghrelin receptor modulators | ABBOTT LABORATORIES | 2005-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060235075-A1 | Analogous compounds of strobilurines and their use as acaricides and insecticides | DDT, RYR1, TPMT | ADRB2 2624/4885TSHR 3510/4885MAPK1 3052/4885 |
| US-20230140941-A1 | NON-ATP/CATALYTIC SITE P38 MITOGEN ACTIVATED PROTEIN KINASE INHIBITORS | MAPK1, MAPK8, MAPK4 | ADRB2 3842/4885TSHR 4570/4885MAPK1 1/4885 |
| US-20060173050-A1 | Inhibitors of c-Jun N-terminal kinases | MAPKAPK3, MAP3K3, MAPK3 | ADRB2 3243/4885TSHR 4439/4885MAPK1 26/4885 |
| US-20210040072-A1 | NTCP Inhibitors | HAVCR2, NPC1, HMGCR | ADRB2 3834/4885TSHR 2808/4885MAPK1 2737/4885 |
| US-11530199-B2 | Analogs for the treatment of disease | MAP4K4, MAP4K5, MAP4K2 | ADRB2 2083/4885TSHR 3146/4885MAPK1 119/4885 |
| US-20050171131-A1 | Diaminopyrimidine derivatives as growth hormone secrectgogue receptor (GHS-R) antagonists | GHSR, GIPR, GPR119 | ADRB2 1999/4885TSHR 348/4885MAPK1 661/4885 |
| US-20050171132-A1 | Diaminopyrimidine derivatives as selective growth hormone secrectgogue receptor (GHS-R) antagonists | GHSR, GIPR, GPR119 | ADRB2 1930/4885TSHR 267/4885MAPK1 577/4885 |
| US-10961231-B2 | NTCP inhibitors | HAVCR2, NPC1, HMGCR | ADRB2 3834/4885TSHR 2808/4885MAPK1 2737/4885 |
| US-20050070712-A1 | Pyrimidine derivatives as ghrelin receptor modulators | GPR119, GIPR, GCGR | ADRB2 1047/4885TSHR 161/4885MAPK1 956/4885 |
| US-11530197-B2 | Analogs for the treatment of disease | MAP4K4, MAP4K5, MAP4K2 | ADRB2 2083/4885TSHR 3146/4885MAPK1 119/4885 |
| US-10399933-B2 | Inhibitors of indoleamine-2,3-dioxygenase for the treatment of cancer | IDO1, IDO2, INMT | ADRB2 1545/4885TSHR 3618/4885MAPK1 1658/4885 |
| US-20210230160-A1 | PHOSPHODIESTERASE INHIBITORS | PDE4A, PDE4B, PDE4C | ADRB2 1074/4885TSHR 3606/4885MAPK1 1153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.