Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD5 | P21918 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | EED | O75530 | 2/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 5/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21047591 | 0.80 | PRKDC (0.40) | NPC1RAB9ATDP1ALDH1A1POLB | |
| SCHEMBL761104 | 0.79 | — | — | |
| SCHEMBL3349858 | 0.79 | ALDH1A1 (0.41) | NPC1RAB9ATDP1ALDH1A1POLB | |
| SCHEMBL4607483 | 0.77 | ALDH1A1 (0.44) | NPC1RAB9AALDH1A1POLBMAPT | |
| SCHEMBL1019181 | 0.76 | NPC1 (0.49) | NPC1RAB9ATDP1ALDH1A1POLB | |
| SCHEMBL5029237 | 0.73 | ADRB1 (0.47) | ALDH1A1KDM4E | |
| SCHEMBL21047699 | 0.73 | PRKDC (0.35) | NPC1RAB9ATDP1ALDH1A1POLB | |
| SCHEMBL15473924 | 0.72 | NCF1 (0.44) | KDM4EADRA1AADRA1BCHRM1 | |
| SCHEMBL20458953 | 0.72 | ADRA1A (0.36) | NPC1RAB9AALDH1A1MAPTKDM4E | |
| SCHEMBL31373496 | 0.71 | ADRA1A (0.35) | ALDH1A1TSHRHSD17B10MAPK1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4187314-A | DOPAMINERGIC ACTIVITY | SMITHKLINE CORPORATION (US) | 1980-02-05 | — | — | US | disclosed |
| US-4111957-A | DOPAMINERGIC | SMITHKLINE CORPORATION (US) | 1978-09-05 | — | — | US | disclosed |