SCHEMBL1146810

SCHEMBL1146810

CC(C)CC(NC(=O)c1ccc(-c2csc(N3CCN(C)CC3)n2)cc1)C(=O)N1CC(C=C(F)F)C2OCC(=O)C21

nearest known ligand 0.88

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CTSK P43235 20/20 0.88
CTSS P25774 10/20 0.88
CTSL P07711 8/20 0.79

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1147024 0.94 CTSK (0.89) CTSKCTSSCTSL
SCHEMBL19633788 0.94 CTSK (1.00) CTSKCTSSCTSL
SCHEMBL11925955 0.94 CTSK (1.00) CTSKCTSSCTSL
SCHEMBL1146969 0.91 CTSK (0.81) CTSKCTSSCTSL
SCHEMBL13450151 0.90 CTSK (0.86) CTSKCTSSCTSL
SCHEMBL12632796 0.90 CTSK (0.86) CTSKCTSSCTSL
SCHEMBL13527944 0.90 CTSK (0.86) CTSKCTSSCTSL
SCHEMBL4727400 0.90 CTSK (0.86) CTSKCTSSCTSL
SCHEMBL31681869 0.90 CTSK (0.86) CTSKCTSSCTSL
SCHEMBL1146804 0.90 CTSK (0.81) CTSKCTSSCTSL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12378209-B2 Protease inhibitors MEDIVIR AB (SE) 2025-08-05 US disclosed
US-20220332690-A1 PROTEASE INHIBITORS MEDIVIR AB (SE) 2022-10-20 US disclosed
US-11312693-B2 Protease inhibitors MEDIVIR AB (SE) 2022-04-26 US disclosed
US-20210017140-A1 PROTEASE INHIBITORS MEDIVIR AB (SE) 2021-01-21 US disclosed
US-10723709-B2 Protease inhibitors MEDIVIR AB (SE) 2020-07-28 US disclosed
US-10329266-B2 Protease inhibitors MEDIVIR AB (SE) 2019-06-25 US disclosed
US-20180327371-A1 PROTEASE INHIBITORS MEDIVIR AB (SE) 2018-11-15 US disclosed
US-20170334867-A1 PROTEASE INHIBITORS MEDIVIR AB (SE) 2017-11-23 US disclosed
US-20170166538-A1 PROTEASE INHIBITORS MEDIVIR AB (SE) 2017-06-15 US disclosed
US-9200006-B2 Protease inhibitors MEDIVIR AB (SE) 2015-12-01 US disclosed
US-20140221654-A1 PROTEASE INHIBITORS MEDIVIR AB (SE) 2014-08-07 US disclosed
US-8735395-B2 Protease inhibitors MEDIVIR AB (SE) 2014-05-27 US disclosed
US-20130231349-A1 PROTEASE INHIBITORS MEDIVIR AB (SE) 2013-09-05 US disclosed
US-8426421-B2 Protease inhibitors MEDIVIR AB (SE) 2013-04-23 US disclosed
US-20120289519-A1 PROTEASE INHIBITORS MEDIVIR AB (SE) 2012-11-15 US disclosed
US-8242119-B2 Protease inhibitors MEDIVIR AB (SE) 2012-08-14 US disclosed
EP-2331548-A1 PROTEASE INHIBITORS Medivir AB (SE) 2011-06-15 EP disclosed
US-20110039862-A1 Protease Inhibitors MEDIVIR AB (SE) 2011-02-17 US disclosed
WO-2010034788-A1 PROTEASE INHIBITORS MEDIVIR AB (SE) 2010-04-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120289519-A1 PROTEASE INHIBITORS F2RL1, F2RL3, PREP CTSK 67/4885CTSS 36/4885CTSL 7/4885
US-10723709-B2 Protease inhibitors CTSK, CTSF, CTSS CTSK 1/4885CTSS 3/4885CTSL 8/4885
US-11312693-B2 Protease inhibitors CTSK, CTSF, CTSS CTSK 1/4885CTSS 3/4885CTSL 8/4885
US-10329266-B2 Protease inhibitors CTSK, CTSF, CTSS CTSK 1/4885CTSS 3/4885CTSL 8/4885
US-12378209-B2 Protease inhibitors MMP26, CTSK, TMPRSS6 CTSK 2/4885CTSS 6/4885CTSL 12/4885
US-20170334867-A1 PROTEASE INHIBITORS CTSK, MMP26, MMP3 CTSK 1/4885CTSS 7/4885CTSL 13/4885
US-20210017140-A1 PROTEASE INHIBITORS CTSK, CTSF, CTSS CTSK 1/4885CTSS 3/4885CTSL 8/4885
US-20110039862-A1 Protease Inhibitors CTSK, CTSF, CTSS CTSK 1/4885CTSS 3/4885CTSL 8/4885
US-20180327371-A1 PROTEASE INHIBITORS CTSK, CTSF, CTSS CTSK 1/4885CTSS 3/4885CTSL 8/4885
US-20170166538-A1 PROTEASE INHIBITORS MMP8, CTSK, CTSS CTSK 2/4885CTSS 3/4885CTSL 7/4885
US-20130231349-A1 PROTEASE INHIBITORS CTSK, CTSF, CTSS CTSK 1/4885CTSS 3/4885CTSL 8/4885
US-20140221654-A1 PROTEASE INHIBITORS CTSK, CTSF, CTSS CTSK 1/4885CTSS 3/4885CTSL 8/4885
US-20220332690-A1 PROTEASE INHIBITORS MMP26, CTSK, TMPRSS6 CTSK 2/4885CTSS 6/4885CTSL 12/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.