Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.47 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.47 |
| ▸ | CXCL8 | P10145 | 3/20 | 0.46 |
| ▸ | CFD | P00746 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.44 |
| ▸ | MMP2 | P08253 | 2/20 | 0.44 |
| ▸ | MMP8 | P22894 | 2/20 | 0.44 |
| ▸ | MMP12 | P39900 | 2/20 | 0.44 |
| ▸ | MMP13 | P45452 | 2/20 | 0.44 |
| ▸ | MMP14 | P50281 | 2/20 | 0.44 |
| ▸ | MMP16 | P51512 | 2/20 | 0.44 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.44 |
| ▸ | UGT1A9 | O60656 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11484601 | 0.98 | AKR1B1 (0.53) | AKR1B1TDP1PTGS2BCAT2CXCL8 | |
| Iodide SCHEMBL31305035 | 0.85 | AKR1B1 (0.73) | AKR1B1TDP1PTGS2BCAT2CXCL8 | |
| SCHEMBL10331853 | 0.84 | L3MBTL1 (0.46) | AKR1B1KDM4ECYP3A4MAPTSLC6A2 | |
| Methyl Alcohol SCHEMBL28299530 | 0.83 | AKR1B1 (0.70) | AKR1B1TDP1PTGS2BCAT2CXCL8 | |
| SCHEMBL30359 | 0.82 | AKR1B1 (0.76) | AKR1B1TDP1PTGS2BCAT2CXCL8 | |
| SCHEMBL29410826 | 0.82 | AKR1B1 (0.76) | AKR1B1TDP1PTGS2BCAT2CXCL8 | |
| SCHEMBL13136706 | 0.81 | AKR1B1 (0.52) | AKR1B1TDP1PTGS2BCAT2CXCL8 | |
| SCHEMBL13136705 | 0.81 | KEAP1 (0.48) | ADRA1AKDM4ECYP3A4MAPTSLC6A2 | |
| Hydrochloric Acid SCHEMBL6767821 | 0.80 | AKR1B1 (0.73) | AKR1B1TDP1PTGS2BCAT2CXCL8 | |
| SCHEMBL28842838 | 0.80 | AKR1B1 (0.73) | AKR1B1TDP1PTGS2BCAT2CXCL8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-54138536-A | — | — | None | — | — | JP | disclosed |
| US-20240025930-A1 | SMALL MOLECULE INHIBITORS SELECTIVE FOR POLO-LIKE KINASE PROTEIN | UNIVERISTY OF SOUTH CAROLINA | 2024-01-25 | — | — | US | disclosed |
| US-11873291-B2 | Quinoline cGAS antagonist compounds | IMMUNESENSOR THERAPEUTICS, INC. (US) | 2024-01-16 | — | — | US | disclosed |
| WO-2021202600-A1 | SMALL MOLECULE INHIBITORS OF INFLUENZA HEMAGGLUTININ | THE SCRIPPS RESEARCH INSTITUTE (US) | 2021-10-07 | — | — | WO | disclosed |
| WO-2019168654-A9 | DNA-TEMPLATED MACROCYCLE LIBRARY | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2019-10-17 | — | — | WO | disclosed |
| US-10188653-B2 | Diacylglycerol acyltransferase 2 inhibitors | PFIZER INC. (US) | 2019-01-29 | — | — | US | disclosed |
| EP-3119757-B1 | DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITORS FOR USE IN THE TREATMENT OF METABOLIC AND RELATED DISORDERS | PFIZER (US) | 2018-05-16 | — | — | EP | disclosed |
| US-20180042926-A1 | DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITORS | PFIZER INC. (US) | 2018-02-15 | — | — | US | disclosed |
| US-9789110-B2 | Diacylglycerol acyltransferase 2 inhibitors | PFIZER INC. (US) | 2017-10-17 | — | — | US | disclosed |
| US-20160303125-A1 | DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITORS | PFIZER INC. (US) | 2016-10-20 | — | — | US | disclosed |
| US-9440949-B2 | Diacylglycerol acyltransferase 2 inhibitors | PFIZER INC. (US) | 2016-09-13 | — | — | US | disclosed |
| WO-2015140658-A1 | DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITORS FOR USE IN THE TREATMENT OF METABOLIC AND RELATED DISORDERS | PFIZER INC. (US) | 2015-09-24 | — | — | WO | disclosed |
| US-20150259323-A1 | DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITORS | PFIZER INC. (US) | 2015-09-17 | — | — | US | disclosed |
| EP-2414350-B1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2014-11-12 | — | — | EP | disclosed |
| WO-2010117635-A1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-10-14 | — | — | WO | disclosed |
| US-4198506-A | INTERMEDIATES FOR THE CORRESPONDING 3-SUBSTITUTED 3-CEPHEM-4-CARBOXYLIC ACIDS | BRISTOL-MYERS COMPANY (US) | 1980-04-15 | — | — | US | disclosed |
| JP-S54138536-A | O-(N-SUBSTITUTED AMINOMETHYL)PHENYLACETICACID AND ITS PREPARATION | BANYU PHARMACEUT CO LTD | 1979-10-27 | — | — | JP | disclosed |
| US-4151352-A | CEPHALOSPORINS, BACTERICIDES | BRISTOL-MYERS COMPANY (US) | 1979-04-24 | — | — | US | disclosed |
| US-4100346-A | Certain 7(o-amino-methyl- or methylaminomethylphenyl- or cyclohexadienyl- or thienylacetamide)-3[1-carboxymethyl-(or ethyl- or propyl-)-tetrazol-5-ylthiomethyl]-3-cephem-4-carboxylic acids | BRISTOL-MYERS COMPANY (US) | 1978-07-11 | — | — | US | disclosed |
| US-4082912-A | ANTIBACTERIAL | BRISTOL-MYERS COMPANY (US) | 1978-04-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150259323-A1 | DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITORS | DGAT2, LCLAT1, DGAT1 | AKR1B1 1783/4885TDP1 694/4885PTGS2 811/4885 |
| US-11873291-B2 | Quinoline cGAS antagonist compounds | CGAS, GLS2, GLS | AKR1B1 3777/4885TDP1 69/4885PTGS2 959/4885 |
| US-10188653-B2 | Diacylglycerol acyltransferase 2 inhibitors | DGAT2, LCLAT1, DGAT1 | AKR1B1 1783/4885TDP1 694/4885PTGS2 811/4885 |
| US-20240025930-A1 | SMALL MOLECULE INHIBITORS SELECTIVE FOR POLO-LIKE KINASE PROTEIN | PLK2, PLK4, PLK3 | AKR1B1 3393/4885TDP1 714/4885PTGS2 3325/4885 |
| US-20160303125-A1 | DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITORS | DGAT2, LCLAT1, DGAT1 | AKR1B1 1783/4885TDP1 694/4885PTGS2 811/4885 |
| US-20180042926-A1 | DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITORS | DGAT2, LCLAT1, DGAT1 | AKR1B1 1783/4885TDP1 694/4885PTGS2 811/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.