Sugi Predict

Sugi Predict / Compounds / SCHEMBL1148732

SCHEMBL1148732

SCHEMBL1148732

CC1CCN(C(=O)Cl)CC1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 5/20 0.59
▸ KMT2A Q03164 2/20 0.57
▸ MEN1 O00255 1/20 0.57
▸ NPC1 O15118 3/20 0.54
▸ ACHE P22303 1/20 0.47
▸ PHGDH O43175 1/20 0.46
▸ MGLL Q99685 1/20 0.46
▸ HPGD P15428 2/20 0.43
▸ SMN1; SMN2 Q16637 2/20 0.43
▸ GAA P10253 1/20 0.43
▸ LMNA P02545 1/20 0.42
▸ TP53 P04637 1/20 0.42
▸ POLB P06746 1/20 0.41
▸ RAB9A P51151 2/20 0.40
▸ APOBEC3A P31941 1/20 0.40
▸ APOBEC3G Q9HC16 1/20 0.40
▸ CA12 O43570 1/20 0.40
▸ CA1 P00915 1/20 0.40
▸ CA2 P00918 1/20 0.40
▸ CA7 P43166 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9954803 0.86 — —
SCHEMBL23887179 0.79 ALDH1A1 (0.37) ALDH1A1KMT2AMEN1NPC1MGLL
SCHEMBL25446918 0.79 ALDH1A1 (0.58) ALDH1A1KMT2AMEN1NPC1ACHE
SCHEMBL27183 0.77 ALDH1A1 (0.56) ALDH1A1KMT2AMEN1NPC1ACHE
SCHEMBL1261911 0.77 ALDH1A1 (0.56) ALDH1A1KMT2AMEN1NPC1ACHE
SCHEMBL1306840 0.77 GPR119 (0.37) ALDH1A1KMT2AMEN1NPC1RAB9A
SCHEMBL14009909 0.76 ALDH1A1 (0.50) ALDH1A1KMT2AMEN1NPC1ACHE
SCHEMBL1283538 0.76 SMN1; SMN2 (0.38) ALDH1A1KMT2AMEN1MGLLSMN1; SMN2
SCHEMBL10280128 0.75 ALDH1A1 (0.54) ALDH1A1KMT2AMEN1NPC1ACHE
SCHEMBL770867 0.75 ALDH1A1 (0.54) ALDH1A1KMT2AMEN1NPC1ACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250353835-A1 N-TETRAZOLYL ARYL UREA-BASED DERIVATIVES, PREPARATION METHOD THEREFOR, AND USE THEREOF HANGZHOU YIRUI PHARMACEUTICAL TECHNOLOGY CO., LTD (CN) 2025-11-20 — — US disclosed
EP-4538261-A1 N-TETRAZOLYL ARYL UREA DERIVATIVES, PREPARATION METHOD THEREFOR, AND USE THEREOF Hangzhou Yirui Pharmaceutical Technology Co., Ltd. (CN) 2025-04-16 — — EP disclosed
CN-117229258-B N-tetrazolyl aryl urea derivative and preparation method and application thereof 杭州壹瑞医药科技有限公司 2024-07-19 — — CN disclosed
CN-117229258-A N-tetrazolyl aryl urea derivative and preparation method and application thereof 杭州壹瑞医药科技有限公司 2023-12-15 — — CN disclosed
WO-2023237015-A1 N-TETRAZOLYL ARYL UREA DERIVATIVES, PREPARATION METHOD THEREFOR, AND USE THEREOF 杭州壹瑞医药科技有限公司 2023-12-14 — — WO disclosed
CN-110678177-B Pyrazole MAGL inhibitors H.隆德贝克有限公司 2023-06-13 — — CN disclosed
EP-3505171-A1 BICYCLIC NITROGENATED HETEROCYCLIC COMPOUND Mitsubishi Tanabe Pharma Corporation (JP) 2019-07-03 — — EP disclosed
US-20190185479-A1 BICYCLIC NITROGENATED HETEROCYCLIC COMPOUND MITSUBISHI TANABE PHARMA CORPORATION (JP) 2019-06-20 — — US disclosed
US-8921404-B2 Azole derivatives in the form of lipase and phospholipase inhibitors SANOFI (FR) 2014-12-30 — — US disclosed
US-20140378436-A9 Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their use and Manufacture EXELIXIS, INC. (US) 2014-12-25 — — US disclosed
CN-1914180-A Indazole derivatives as hormone sensitive lipase inhibitors SANOFI AVENTIS DEUTSCHLAND (DE) 2007-02-14 — — CN disclosed
WO-2006111321-A1 AZOLE DERIVATIVES IN THE FORM OF LIPASE AND PHOSPHOLIPASE INHIBITORS SANOFI-AVENTIS (DE) 2006-10-26 — — WO disclosed
EP-1713779-A1 INDAZOLE DERIVATIVES AS INHIBITORS OF HORMONE-SENSITIVE LIPASES Sanofi-Aventis Deutschland GmbH (DE) 2006-10-25 — — EP disclosed
US-20050197348-A1 Indazole derivatives as inhibitors of hormone sensitive lipase AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2005-09-08 — — US disclosed
WO-2005073199-A1 INDAZOLE DERIVATIVES AS INHIBITORS OF HORMONE-SENSITIVE LIPASES SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2005-08-11 — — WO disclosed
US-5602151-A ADMINISTERING TO MAMMALS TO REDUCE SERUM CHOLESTEROL LEVELS AMERICAN HOME PRODUCTS CORPORATION (US) 1997-02-11 — — US disclosed
US-5512565-A REDUCE CHOLESTEROL ABSORPTION IN MAMMALS AMERICAN HOME PRODUCTS CORPORATION (US) 1996-04-30 — — US disclosed
US-5391571-A Cholesterol ester hydrolase inhibitors AMERICAN HOME PRODUCTS CORPORATION (US) 1995-02-21 — — US disclosed
US-5373009-A Anticholesterolemic agents AMERICAN HOME PRODUCTS CORPORATION (US) 1994-12-13 — — US disclosed
EP-0428385-A1 Cholesterol ester hydrolase inhibitors AMERICAN HOME PRODUCTS CORPORATION (US) 1991-05-22 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190185479-A1 BICYCLIC NITROGENATED HETEROCYCLIC COMPOUND PDE7B, PDE3A, PDE7A ALDH1A1 1644/4885KMT2A 1923/4885MEN1 1320/4885
US-20140378436-A9 Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their use and Manufacture MTOR, RICTOR, PIK3CA ALDH1A1 3395/4885KMT2A 2645/4885MEN1 3183/4885
US-20250353835-A1 N-TETRAZOLYL ARYL UREA-BASED DERIVATIVES, PREPARATION METHOD THEREFOR, AND USE THEREOF BDKRB1, BDKRB2, UTS2R ALDH1A1 2190/4885KMT2A 2463/4885MEN1 1907/4885
US-20050197348-A1 Indazole derivatives as inhibitors of hormone sensitive lipase LIPE, PNLIP, CEL ALDH1A1 479/4885KMT2A 4174/4885MEN1 2534/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.