Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPY1R | P25929 | 1/20 | 0.33 |
| ▸ | ALB | P02768 | 1/20 | 0.33 |
| ▸ | FNTA | P49354 | 1/20 | 0.31 |
| ▸ | FNTB | P49356 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11502077 | 0.94 | ALDH1A1 (0.33) | NPY1RALBFNTAFNTBSPHK1 | |
| SCHEMBL11501597 | 0.81 | KMT2A (0.46) | NPY1RALDH1A1 | |
| SCHEMBL11501551 | 0.77 | KDM4E (0.33) | KDM4ELMNAGAASMN1; SMN2NPY1R | |
| SCHEMBL8032200 | 0.77 | EPHX1 (0.47) | SPHK1 | |
| SCHEMBL11460240 | 0.74 | USP2 (0.41) | KDM4ESPHK1ALDH1A1 | |
| SCHEMBL3070903 | 0.73 | EPHX1 (0.40) | ALOX15SPHK1 | |
| SCHEMBL11501889 | 0.73 | KMT2A (0.47) | SMN1; SMN2NPY1RALDH1A1 | |
| SCHEMBL11501702 | 0.72 | SPHK1 (0.43) | SPHK1 | |
| SCHEMBL11501651 | 0.72 | MTNR1A (0.48) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL11502016 | 0.70 | TSHR (0.35) | SMN1; SMN2NPY1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4163022-A | ANTIPLAQUE AGENTS | COOPER LABORATORIES, INC. (US) | 1979-07-31 | — | — | US | disclosed |