Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1152353 | 1.00 | HDAC8 (0.33) | HDAC8 | |
| SCHEMBL3401174 | 0.99 | HDAC8 (0.33) | HDAC8 | |
| SCHEMBL3401171 | 0.99 | HDAC8 (0.33) | HDAC8 | |
| Hydrochloric Acid SCHEMBL4806214 | 0.82 | NPSR1 (0.31) | HDAC8 | |
| SCHEMBL5199374 | 0.81 | HDAC8 (0.31) | HDAC8 | |
| Hydrochloric Acid SCHEMBL4803365 | 0.80 | KDM4E (0.43) | — | |
| Hydrochloric Acid SCHEMBL1151781 | 0.72 | HDAC8 (0.33) | HDAC8 | |
| Hydrochloric Acid SCHEMBL1151788 | 0.72 | HDAC8 (0.33) | HDAC8 | |
| SCHEMBL483981 | 0.71 | HDAC8 (0.34) | HDAC8 | |
| SCHEMBL483985 | 0.71 | HDAC8 (0.34) | HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11896700-B2 | Process for treating keratin fibers using an anhydrous composition comprising a compound of azomethine type comprising two pyrazolopyridine units and an aqueous composition | L'OREAL (FR) | 2024-02-13 | — | — | US | disclosed |
| US-20230137804-A1 | PROCESS FOR TREATING KERATIN FIBERS USING AN ANHYDROUS COMPOSITION COMPRISING A COMPOUND OF AZOMETHINE TYPE COMPRISING TWO PYRAZOLOPYRIDINE UNITS AND AN AQUEOUS COMPOSITION | L'OREAL (FR) | 2023-05-04 | — | — | US | disclosed |
| EP-3474815-B1 | PROCESS FOR TREATING KERATIN FIBERS USING AN ANHYDROUS COMPOSITION COMPRISING A COMPOUND OF AZOMETHINE TYPE COMPRISING TWO PYRAZOLOPYRIDINE UNITS AND AN AQUEOUS COMPOSITION | OREAL (FR) | 2022-03-16 | — | — | EP | disclosed |
| EP-3475278-B1 | (DIS)SYMMETRIC AZOMETHINE-TYPE DIRECT DYE COMPRISING AT LEAST ONE PYRAZOLOPYRIDINE UNIT, PROCESS FOR DYEING KERATIN FIBERS USING THIS DYE | OREAL (FR) | 2021-12-22 | — | — | EP | disclosed |
| US-11117864-B2 | Use for dyeing keratin fibers of a compound of azomethine type bearing a quinoline-derived unit | L'OREAL (FR) | 2021-09-14 | — | — | US | disclosed |
| US-11007131-B2 | Dyeing composition comprising a direct dye of triarylmethane structure, and a silicone | L'OREAL (FR) | 2021-05-18 | — | — | US | disclosed |
| US-11000464-B2 | Dyeing composition at acidic pH comprising a direct dye of triarylmethane structure | L'OREAL (FR) | 2021-05-11 | — | — | US | disclosed |
| EP-3393441-B1 | DYEING COMPOSITION COMPRISING A DIRECT DYE OF TRIARYLMETHANE STRUCTURE, AND A SILICONE | OREAL (FR) | 2021-01-20 | — | — | EP | disclosed |
| EP-3474814-B1 | A COMPOUND OF AZOMETHINE TYPE BEARING A QUINOLINE-DERIVED UNIT AND ITS USE FOR DYEING KERATIN FIBERS | OREAL (FR) | 2020-11-11 | — | — | EP | disclosed |
| US-20200308117-A1 | USE FOR DYEING KERATIN FIBERS OF A COMPOUND OF AZOMETHINE TYPE BEARING A QUINOLINE-DERIVED UNIT | L'OREAL (FR) | 2020-10-01 | — | — | US | disclosed |
| US-7678157-B2 | Use of an anionic hydrotrope for the colouring of keratinous fibres, composition comprising it and colouring processes employing it | L'OREAL S.A. (FR) | 2010-03-16 | — | — | US | disclosed |
| US-20100031453-A1 | COMPOSITION FOR DYEING KERATIN FIBRES, COMPRISING A CATIONIC DIAZO DIRECT DYE CONTAINING A 2-IMIDAZOLIUM UNIT | L'OREAL S.A. (FR) | 2010-02-11 | — | — | US | disclosed |
| US-20090300856-A1 | SPECIFIC MONOCATIONIC MONOCHROMOPHORIC COMPOUNDS OF HYDRAZONE TYPE COMPRISING A 2-, 4-PYRIDINIUM OR 2-, 4-QUINOLINIUM UNIT, SYNTHESIS THEREOF, DYE COMPOSITIONS CONTAINING THEM, AND METHOD FOR DYEING KERATIN FIBRES | L'OREAL S.A. (FR) | 2009-12-10 | — | — | US | disclosed |
| US-7582123-B2 | Coloring composition comprising at least one azomethine compound with a pyrazolinone unit | L'OREAL S.A. (FR) | 2009-09-01 | — | — | US | disclosed |
| US-7569079-B2 | Polycationic monochromophoric hydrazone compounds, dye compositions comprising such polycationic compounds and dyeing process using them | L'OREAL S.A. (FR) | 2009-08-04 | — | — | US | disclosed |
| US-7559956-B2 | Use of a cationic hydrotrope for the direct dyeing of keratinous fibres, composition comprising it and colouring processes employing it | L'OREAL S.A. (FR) | 2009-07-14 | — | — | US | disclosed |
| US-20090044348-A1 | Coloring composition comprising at least one azomethine compound with a pyrazolinone unit | L'OREAL S.A. (FR) | 2009-02-19 | — | — | US | disclosed |
| US-20080263785-A1 | Polycationic monochromophoric hydrazone compounds, dye compositions comprising such polycationic compounds and dyeing process using them | L'OREAL S.A. (FR) | 2008-10-30 | — | — | US | disclosed |
| US-20080086824-A1 | Use of a cationic hydrotrope for the direct dyeing of keratinous fibres, composition comprising it and colouring processes employing it | L'OREAL S.A. (FR) | 2008-04-17 | — | — | US | disclosed |
| US-20080052840-A1 | Use of an anionic hydrotrope for the colouring of keratinous fibres, composition comprising it and colouring processes employing it | L'OREAL S.A. (FR) | 2008-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090300856-A1 | SPECIFIC MONOCATIONIC MONOCHROMOPHORIC COMPOUNDS OF HYDRAZONE TYPE COMPRISING A 2-, 4-PYRIDINIUM OR 2-, 4-QUINOLINIUM UNIT, SYNTHESIS THEREOF, DYE COMPOSITIONS CONTAINING THEM, AND METHOD FOR DYEING KERATIN FIBRES | KRT18, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, H1-5 | HDAC8 1483/4885 |
| US-11896700-B2 | Process for treating keratin fibers using an anhydrous composition comprising a compound of azomethine type comprising two pyrazolopyridine units and an aqueous composition | KRT18, DPYD, CKAP4 | HDAC8 2606/4885 |
| US-11000464-B2 | Dyeing composition at acidic pH comprising a direct dye of triarylmethane structure | KRT18, TYR, DSG1 | HDAC8 593/4885 |
| US-20080052840-A1 | Use of an anionic hydrotrope for the colouring of keratinous fibres, composition comprising it and colouring processes employing it | KRT18, F12, H1-3 | HDAC8 3524/4885 |
| US-20200308117-A1 | USE FOR DYEING KERATIN FIBERS OF A COMPOUND OF AZOMETHINE TYPE BEARING A QUINOLINE-DERIVED UNIT | KRT18, TUBB1, VIM | HDAC8 2567/4885 |
| US-11007131-B2 | Dyeing composition comprising a direct dye of triarylmethane structure, and a silicone | KRT18, TUBB1, TUBB3 | HDAC8 1120/4885 |
| US-11117864-B2 | Use for dyeing keratin fibers of a compound of azomethine type bearing a quinoline-derived unit | KRT18, TUBB1, VIM | HDAC8 2567/4885 |
| US-20230137804-A1 | PROCESS FOR TREATING KERATIN FIBERS USING AN ANHYDROUS COMPOSITION COMPRISING A COMPOUND OF AZOMETHINE TYPE COMPRISING TWO PYRAZOLOPYRIDINE UNITS AND AN AQUEOUS COMPOSITION | KRT18, DPYD, CKAP4 | HDAC8 2606/4885 |
| US-20090044348-A1 | Coloring composition comprising at least one azomethine compound with a pyrazolinone unit | KRT18, KMO, TMPO | HDAC8 3231/4885 |
| US-20080263785-A1 | Polycationic monochromophoric hydrazone compounds, dye compositions comprising such polycationic compounds and dyeing process using them | KRT18, CKMT1A; CKMT1B, XRCC5 | HDAC8 515/4885 |
| US-20080086824-A1 | Use of a cationic hydrotrope for the direct dyeing of keratinous fibres, composition comprising it and colouring processes employing it | KRT18, H1-0, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | HDAC8 3927/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.