Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | STK3 | Q13188 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11519411 | 0.85 | RAB9A (0.47) | TYK2NPC1RAB9AKDM4EMAPT | |
| SCHEMBL11523266 | 0.81 | RAB9A (0.45) | NPC1RAB9AKDM4EMEN1MAPT | |
| SCHEMBL11523665 | 0.80 | HCRTR1 (0.48) | TYK2NPC1RAB9AMAP4K4CSNK2A1 | |
| SCHEMBL11521954 | 0.79 | TYK2 (0.44) | TYK2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL11522756 | 0.78 | KDM4E (0.48) | TYK2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL11524682 | 0.76 | TYK2 (0.41) | TYK2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL8657584 | 0.75 | RAB9A (0.57) | NPC1RAB9ARPS6KA3MEN1MAPT | |
| SCHEMBL11520381 | 0.73 | NR1H2 (0.45) | DYRK3PRKD3MAP4K4CDK1CDK2 | |
| SCHEMBL11524433 | 0.73 | MEN1 (0.45) | NPC1KDM4EALDH1A1MAPK1RORC | |
| SCHEMBL11524573 | 0.73 | RAB9A (0.46) | TYK2NPC1RAB9AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4160834-A | INSECTICIDES | ELI LILLY AND COMPANY (US) | 1979-07-10 | — | — | US | disclosed |
| US-4083977-A | Novel insecticidal 1-(substituted benzoyl)-3-(substituted pyrazinyl)ureas | ELI LILLY AND COMPANY (US) | 1978-04-11 | — | — | US | disclosed |