Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.60 |
| ▸ | CACNA1G | O43497 | 4/20 | 0.60 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.60 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.60 |
| ▸ | HTR2A | P28223 | 4/20 | 0.60 |
| ▸ | DRD3 | P35462 | 4/20 | 0.60 |
| ▸ | DRD2 | P14416 | 3/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.60 |
| ▸ | HTR2C | P28335 | 3/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.60 |
| ▸ | HRH1 | P35367 | 3/20 | 0.60 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.60 |
| ▸ | HTR6 | P50406 | 3/20 | 0.60 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.60 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.60 |
| ▸ | MTOR | P42345 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10281563 | 0.88 | OPRM1 (0.65) | OPRM1CACNA1GCACNA1HOPRK1HTR2A | |
| SCHEMBL11929305 | 0.85 | HTR2A (0.68) | OPRM1CACNA1GCACNA1HOPRK1HTR2A | |
| SCHEMBL30079786 | 0.84 | CACNA1G (0.76) | OPRM1CACNA1GCACNA1HOPRK1HTR2A | |
| SCHEMBL24709131 | 0.84 | CACNA1G (0.76) | OPRM1CACNA1GCACNA1HOPRK1HTR2A | |
| SCHEMBL11925195 | 0.82 | SLC6A2 (0.65) | OPRM1CACNA1GCACNA1HOPRK1HTR2A | |
| SCHEMBL20368998 | 0.80 | SLC6A2 (0.62) | OPRM1CACNA1GCACNA1HOPRK1HTR2A | |
| SCHEMBL1152078 | 0.79 | CACNA1G (0.55) | OPRM1CACNA1GCACNA1HOPRK1HTR2A | |
| SCHEMBL31000433 | 0.77 | CACNA1G (0.84) | OPRM1CACNA1GCACNA1HOPRK1HTR2A | |
| SCHEMBL24708799 | 0.77 | CACNA1G (0.84) | OPRM1CACNA1GCACNA1HOPRK1HTR2A | |
| SCHEMBL11929005 | 0.77 | SIGMAR1 (0.59) | OPRM1CACNA1GCACNA1HOPRK1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130289024-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF FILOVIRUS-MEDIATED DISEASES | U.S. ARMY MEDICAL RESEARCH AND MATERIEL COMMAND | 2013-10-31 | — | — | US | disclosed |
| US-8475804-B2 | Compositions and methods for treatment of filovirus-mediated diseases | U.S. ARMY MEDICAL RESEARCH AND MATERIAL COMMAND (US) | 2013-07-02 | — | — | US | disclosed |
| US-20110028564-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF FILOVIRUS-MEDIATED DISEASES | ZALICUS INC. | 2011-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028564-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF FILOVIRUS-MEDIATED DISEASES | FLNA, FLNB, PIGS | OPRM1 3829/4885CACNA1G 3832/4885CACNA1H 4234/4885 |
| US-20130289024-A1 | COMPOSITIONS AND METHODS FOR TREATMENT OF FILOVIRUS-MEDIATED DISEASES | FLNA, FLNB, PIGS | OPRM1 3829/4885CACNA1G 3832/4885CACNA1H 4234/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.