Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | ATF4 | P18848 | 4/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | OGG1 | O15527 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.58 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4422333 | 0.90 | ALDH1A1 (0.73) | ALDH1A1OGG1MEN1KMT2AKDM4E | |
| SCHEMBL4413701 | 0.85 | ALDH1A1 (0.67) | ALDH1A1OGG1NPC1RAB9AMEN1 | |
| SCHEMBL15426830 | 0.85 | ALDH1A1 (0.68) | ALDH1A1OGG1RAB9AMEN1KMT2A | |
| SCHEMBL1255820 | 0.83 | ATF4 (0.63) | ALDH1A1ATF4NPSR1MEN1KMT2A | |
| SCHEMBL11431811 | 0.82 | NPC1 (0.58) | ALDH1A1ATF4NPSR1NPC1RAB9A | |
| SCHEMBL21004114 | 0.82 | L3MBTL1 (0.63) | ALDH1A1ATF4NPSR1NPC1RAB9A | |
| SCHEMBL6761507 | 0.82 | ALDH1A1 (0.51) | ALDH1A1NPSR1RAB9AMEN1KMT2A | |
| SCHEMBL12693872 | 0.81 | KMT2A (0.61) | ALDH1A1ATF4NPSR1NPC1RAB9A | |
| SCHEMBL4409512 | 0.81 | ALDH1A1 (0.63) | ALDH1A1OGG1MEN1KMT2AL3MBTL1 | |
| SCHEMBL11872758 | 0.81 | ALDH1A1 (0.63) | ALDH1A1OGG1NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250115563-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC | 2025-04-10 | — | — | US | disclosed |
| EP-3704098-B1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2024-01-24 | — | — | EP | disclosed |
| CN-112154142-B | Modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2023-11-21 | — | — | CN | disclosed |
| US-20230144871-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ABBVIE INC. | 2023-05-11 | — | — | US | disclosed |
| US-20230083885-A1 | MODULATORS OF INTEGRATED STRESS RESPONSE PATHWAY | INTEGRAL BIOSCIENCES PVT. LTD. (IN) | 2023-03-16 | — | — | US | disclosed |
| WO-2022212902-A1 | MODULATORS OF INTEGRATED STRESS RESPONSE PATHWAY | ALTOS LABS, INC. (US) | 2022-10-06 | — | — | WO | disclosed |
| US-20210113532-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2021-04-22 | — | — | US | disclosed |
| EP-3778575-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2021-02-17 | — | — | EP | disclosed |
| CN-112154142-A | Modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2020-12-29 | — | — | CN | disclosed |
| CN-108218848-B | Trifluoromethyl pyridine bisoxadiazole (ether) derivative and application thereof | 贵州大学 | 2020-12-18 | — | — | CN | disclosed |
| US-10864196-B2 | Modulators of the integrated stress pathway | CALICO LIFE SCIENCES, LLC (US) | 2020-12-15 | — | — | US | disclosed |
| US-20200361881-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ABBVIE INC. | 2020-11-19 | — | — | US | disclosed |
| EP-3704098-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2020-09-09 | — | — | EP | disclosed |
| EP-3452454-B1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2020-07-08 | — | — | EP | disclosed |
| US-20190142806-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ABBVIE INC. | 2019-05-16 | — | — | US | disclosed |
| CN-109641853-A | Modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2019-04-16 | — | — | CN | disclosed |
| EP-3452454-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2019-03-13 | — | — | EP | disclosed |
| WO-2017193030-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES (US) | 2017-11-09 | — | — | WO | disclosed |
| US-4179439-A | Rifamycins and method for their preparation | INTREPRINDEREA DE ANTIBIOTICE IASI (RO) | 1979-12-18 | — | — | US | disclosed |
| US-3972905-A | FUNGICIDE | BAYER AKTIENGESELLSCHAFT (DT) | 1976-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190142806-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | ALDH1A1 3433/4885ATF4 1/4885NPSR1 1473/4885 |
| US-20230144871-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | ALDH1A1 3433/4885ATF4 1/4885NPSR1 1473/4885 |
| US-20230083885-A1 | MODULATORS OF INTEGRATED STRESS RESPONSE PATHWAY | ATF4, ATF1, DDIT3 | ALDH1A1 4237/4885ATF4 1/4885NPSR1 816/4885 |
| US-20210113532-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | ALDH1A1 3433/4885ATF4 1/4885NPSR1 1473/4885 |
| US-20200361881-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | ALDH1A1 3433/4885ATF4 1/4885NPSR1 1473/4885 |
| US-10864196-B2 | Modulators of the integrated stress pathway | ATF4, ATF1, DDIT3 | ALDH1A1 3433/4885ATF4 1/4885NPSR1 1473/4885 |
| US-20250115563-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, DDIT3 | ALDH1A1 3433/4885ATF4 1/4885NPSR1 1473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.