SCHEMBL11548835

SCHEMBL11548835

COP(C)(=O)OCC(=O)c1ccoc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 1/20 0.45
CYP3A4 P08684 1/20 0.44
MAPT P10636 4/20 0.40
KMT2A Q03164 4/20 0.40
MEN1 O00255 2/20 0.40
KDM4E B2RXH2 1/20 0.40
ALDH1A1 P00352 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C9 P11712 1/20 0.40
HPGD P15428 1/20 0.40
CYP2C19 P33261 1/20 0.40
PTK2 Q05397 1/20 0.37
CETP P11597 1/20 0.36
GPR52 Q9Y2T5 1/20 0.35
POLB P06746 3/20 0.34
LMNA P02545 1/20 0.34
PTPN1 P18031 1/20 0.34
PTPN6 P29350 1/20 0.34
PTPN11 Q06124 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10878397 0.78 POLB (0.57) TRPA1CYP3A4MAPTKMT2AMEN1
SCHEMBL9255947 0.76 NPC1 (0.47) CYP3A4MAPTKMT2AMEN1ALDH1A1
SCHEMBL9250126 0.75 NPC1 (0.44) MAPTKMT2AMEN1KDM4EPOLB
SCHEMBL9258798 0.72 CES2 (0.43) MAPTKMT2AMEN1ALDH1A1LMNA
SCHEMBL9254186 0.71 GSK3B (0.50) MAPTKMT2AMEN1KDM4EALDH1A1
SCHEMBL9254905 0.71 NPC1 (0.46) MAPTKMT2AMEN1KDM4EALDH1A1
SCHEMBL4459301 0.70 TRPA1 (0.53) TRPA1CYP3A4MAPTKMT2AMEN1
SCHEMBL6627157 0.69
SCHEMBL15988633 0.68 TRPA1 (0.69) TRPA1CYP3A4MAPTKMT2AMEN1
SCHEMBL9316270 0.68 LMNA (0.53) TRPA1CYP3A4MAPTKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4143051-A GREATER TISSUE SPECIFICITY OF ACTION PFIZER INC. (US) 1979-03-06 US disclosed
US-4113723-A TISSUE SPECIFICITY PFIZER INC. (US) 1978-09-12 US disclosed
US-4102894-A TISSUE SPECIFICITY PFIZER INC. (US) 1978-07-25 US disclosed
US-4080368-A PROSTAGLANDINS PFIZER INC. (US) 1978-03-21 US disclosed
US-3980642-A 15-Substitute D-ω-pentanorprostaglandins PFIZER INC. (US) 1976-09-14 US disclosed
US-3956284-A INCREASED TISSUE SPECIFITY OF ACTION PFIZER INC. (US) 1976-05-11 US disclosed