Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | STAT1 | P42224 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11548970 | 1.00 | L3MBTL1 (0.44) | L3MBTL1TDP1ESR2ALDH1A1SMN1; SMN2 | |
| SCHEMBL11545098 | 0.84 | ALDH1A1 (0.47) | L3MBTL1TDP1ESR2ALDH1A1SMN1; SMN2 | |
| SCHEMBL11546013 | 0.81 | MCL1 (0.40) | ALDH1A1KDM4EPKMMAPTMCL1 | |
| SCHEMBL11545889 | 0.74 | LMNA (0.41) | TDP1ALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL11544478 | 0.74 | LMNA (0.44) | SMN1; SMN2NPC1RAB9AHPGDMAPT | |
| SCHEMBL11544481 | 0.74 | LMNA (0.44) | SMN1; SMN2NPC1RAB9AHPGDMAPT | |
| SCHEMBL11545105 | 0.74 | L3MBTL1 (0.45) | L3MBTL1TDP1ESR2ALDH1A1TSHR | |
| SCHEMBL11548967 | 0.73 | ALDH1A1 (0.47) | L3MBTL1TDP1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL11544030 | 0.72 | LMNA (0.45) | ALDH1A1SMN1; SMN2KDM4ENPC1PKM | |
| SCHEMBL10422274 | 0.69 | HSD17B10 (0.58) | L3MBTL1TDP1ALDH1A1SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4179513-A | Indole-2-carboxylic acids to effect CNS depressant activity | WARNER-LAMBERT COMPANY (US) | 1979-12-18 | — | — | US | disclosed |
| US-4117129-A | INDOLOBENZOXAZEPINES AS CNS DEPRESSANTS | WARNER-LAMBERT COMPANY (US) | 1978-09-26 | — | — | US | disclosed |
| US-4066660-A | INTERMEDIATES IN THE PREPARATION OF INDOLOBENZOXAZEPINES | WARNER-LAMBERT COMPANY (US) | 1978-01-03 | — | — | US | disclosed |