6-Hydroxyluteolin

6-Hydroxyluteolin

SCHEMBL1155724

O=c1cc(-c2ccc(O)c(O)c2)oc2cc(O)c(O)c(O)c12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 5/20 0.76
▸ PTPRS Q13332 5/20 0.76
▸ AMY1A P0DUB6 4/20 0.76
▸ CYP1A1 P04798 3/20 0.76
▸ CYP1B1 Q16678 3/20 0.76
▸ FTO Q9C0B1 3/20 0.76
▸ GABRP O00591 2/20 0.76
▸ GABRD O14764 2/20 0.76
▸ FBP1 P09467 2/20 0.76
▸ GABRA1 P14867 2/20 0.76
▸ GABRB1 P18505 2/20 0.76
▸ GABRG2 P18507 2/20 0.76
▸ UGT1A1 P22309 2/20 0.76
▸ GABRB3 P28472 2/20 0.76
▸ GABRA5 P31644 2/20 0.76
▸ GABRA3 P34903 2/20 0.76
▸ GRK6 P43250 2/20 0.76
▸ GABRA2 P47869 2/20 0.76
▸ GABRB2 P47870 2/20 0.76
▸ GABRA4 P48169 2/20 0.76

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
6-Hydroxyluteolin SCHEMBL30217544 1.00 KMT2A (0.76) KMT2APTPRSAMY1ACYP1A1CYP1B1
6-Hydroxyluteolin SCHEMBL29887622 1.00 KMT2A (0.76) KMT2APTPRSAMY1ACYP1A1CYP1B1
6-Hydroxyluteolin SCHEMBL29929561 1.00 KMT2A (0.76) KMT2APTPRSAMY1ACYP1A1CYP1B1
SCHEMBL11662442 0.87 PTPRS (0.74) KMT2APTPRSAMY1ACYP1A1CYP1B1
SCHEMBL5981301 0.87 ABCB1 (0.73) KMT2APTPRSAMY1ACYP1A1CYP1B1
Scutellarein SCHEMBL29004586 0.86 KMT2A (1.00) KMT2APTPRSAMY1ACYP1A1CYP1B1
Scutellarein SCHEMBL142093 0.86 KMT2A (1.00) KMT2APTPRSAMY1ACYP1A1CYP1B1
Scutellarein SCHEMBL29692708 0.86 KMT2A (1.00) KMT2APTPRSAMY1ACYP1A1CYP1B1
Scutellarein SCHEMBL1900314 0.85 KMT2A (0.97) KMT2APTPRSAMY1ACYP1A1CYP1B1
Scutellarein SCHEMBL15090395 0.85 KMT2A (0.97) KMT2APTPRSAMY1ACYP1A1CYP1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 232 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4698662-A2 REGULATABLE CONTROLLED EXPRESSION OF A TRANSGENE IN PRIMATES AskBio Inc. (US) 2026-02-25 — — EP claimed
WO-2024220449-A9 REGULATABLE CONTROLLED EXPRESSION OF A TRANSGENE IN PRIMATES AskBio Inc. (US) 2025-04-03 — — WO claimed
US-20250011393-A1 FLAVONOID-COLLAGEN CROSSLINKED ANTIOXIDANT HYDROGEL NORTH CAROLINA STATE UNIVERSITY 2025-01-09 — — US claimed
US-12163004-B2 Polymer composites WARNER BABCOCK INSTITUTE FOR GREEN CHEMISTRY, LLC (US) 2024-12-10 — — US claimed
WO-2024220449-A2 REGULATABLE CONTROLLED EXPRESSION OF A TRANSGENE IN PRIMATES ASKLEPIOS BIOPHARMACEUTICAL, INC. (US) 2024-10-24 — — WO claimed
US-20240315965-A1 COMPOSITIONS AND METHODS RELATED TO PHARMACEUTICAL EXCIPIENTS Natural Extraction Systems, LLC (US) 2024-09-26 — — US claimed
WO-2023219526-A1 MULTITARGET ANTIVIRAL DIETARY SUPPLEMENT PROKIN MILAN (RS) 2023-11-16 — — WO claimed
US-20230089351-A1 METHODS RELATED TO BIOACTIVE AGENTS THAT CONVERT FROM ANIONS TO MOLECULES Natural Extraction Systems, LLC (US) 2023-03-23 — — US claimed
WO-2022182523-A1 COMPOSITIONS RELATED TO BIOACTIVE AGENTS THAT CONVERT FROM ANIONS TO MOLECULES Natural Extraction Systems, LLC (US) 2022-09-01 — — WO claimed
WO-2022182527-A1 COMPOSITIONS AND METHODS RELATED TO PHARMACEUTICAL EXCIPIENTS Natural Extraction Systems, LLC (US) 2022-09-01 — — WO claimed
US-20030118536-A1 Topical compositions and methods for treatment of adverse effects of ionizing radiation QUIGLEY CORPORATION, THE 2003-06-26 — — US claimed
US-20030105031-A1 Methods for the treatment of skin disorders QUIGLEY CORPORATION, THE 2003-06-05 — — US claimed
US-20030103954-A1 Oral compositions and methods for prevention, reduction and treatment of radiation injury QUIGLEY CORPORATION, THE 2003-06-05 — — US claimed
US-20030105027-A1 Nutritional supplements and methods for prevention, reduction and treatment of radiation injury QUIGLEY CORPORATION, THE 2003-06-05 — — US claimed
WO-2003039452-A2 NUTRITIONAL SUPPLEMENTS AND METHODS FOR PREVENTION, REDUCTION AND TREATMENT OF RADIATION INJURY THE QUIGLEY CORPORATION (US) 2003-05-15 — — WO claimed
US-6555573-B2 Comprising a cold compounded mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor, antioxidant and carrier; side effect reduction; partial recovery of neurological function in some cases THE QUIGLEY CORPORATION 2003-04-29 — — US claimed
US-20020165207-A1 Compositions and methods for the treatment of diabetic neuropathy QUIGLEY CORPORATION, THE 2002-11-07 — — US claimed
US-6451837-B1 Neuroprotective effects of mitogen-activated protein kinase (MAPK) cascade inhibitors BASKYS ANDRIUS (US) 2002-09-17 — — US claimed
US-20020115618-A1 Method and composition for the topical treatment of diabetic neuropathy QUIGLEY CORPORATION, THE 2002-08-22 — — US claimed
WO-2002049575-A2 METHOD AND COMPOSITION FOR THE TREATMENT OF DIABETIC NEUROPATHY THE QUIGLEY CORPORATION (US) 2002-06-27 — — WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030103954-A1 Oral compositions and methods for prevention, reduction and treatment of radiation injury FOXO3, BAX, GSTK1 KMT2A 4811/4885PTPRS 4470/4885AMY1A 2042/4885
US-20230089351-A1 METHODS RELATED TO BIOACTIVE AGENTS THAT CONVERT FROM ANIONS TO MOLECULES FABP2, FABP4, GUSB KMT2A 4742/4885PTPRS 4527/4885AMY1A 1499/4885
US-20030105027-A1 Nutritional supplements and methods for prevention, reduction and treatment of radiation injury FOXO3, NQO1, FOXO1 KMT2A 4745/4885PTPRS 4377/4885AMY1A 2369/4885
US-20030105031-A1 Methods for the treatment of skin disorders TYR, CUTA, NFATC1 KMT2A 2226/4885PTPRS 1394/4885AMY1A 3483/4885
US-20030118536-A1 Topical compositions and methods for treatment of adverse effects of ionizing radiation GSTK1, FOXO3, SIK2 KMT2A 4723/4885PTPRS 4425/4885AMY1A 2692/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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