Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Benzene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.75 |
| ▸ | TP53 | P04637 | 1/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzene SCHEMBL17667988 | 1.00 | TSHR (0.75) | TSHRTP53ALDH1A1NAPRTTDP1 | |
| Benzene SCHEMBL9691214 | 1.00 | TSHR (0.75) | TSHRTP53ALDH1A1NAPRTTDP1 | |
| Benzene SCHEMBL11806105 | 1.00 | TSHR (0.75) | TSHRTP53ALDH1A1NAPRTTDP1 | |
| Benzene SCHEMBL525713 | 1.00 | — | — | |
| Benzene SCHEMBL9239251 | 1.00 | — | — | |
| Benzene SCHEMBL10829587 | 1.00 | TSHR (0.75) | TSHRTP53ALDH1A1NAPRTTDP1 | |
| Benzene SCHEMBL27448013 | 1.00 | TSHR (0.75) | TSHRTP53ALDH1A1NAPRTTDP1 | |
| Benzene SCHEMBL905178 | 1.00 | TSHR (0.75) | TSHRTP53ALDH1A1NAPRTTDP1 | |
| Benzene SCHEMBL28756748 | 0.89 | TP53 (0.60) | TSHRTP53 | |
| Benzene SCHEMBL28600795 | 0.89 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114434904-A | Epoxy resin copper-clad plate and preparation method thereof | 安徽鸿海新材料股份有限公司 | 2022-05-06 | — | — | CN | claimed |
| CN-115627637-A | Production method of low-dielectric electronic-grade glass fiber cloth | 建滔(清远)电子材料有限公司 | 2023-01-20 | — | — | CN | disclosed |
| CN-115260640-B | High-temperature-resistant cable insulating material and preparation method thereof | 河北尚华塑料科技有限公司 | 2022-12-20 | — | — | CN | disclosed |
| CN-115260640-A | High-temperature-resistant cable insulating material and preparation method thereof | 河北尚华塑料科技有限公司 | 2022-11-01 | — | — | CN | disclosed |
| CN-113088210-B | Flame-retardant adhesive tape for wrapping lithium ion battery and preparation method thereof | 东莞澳中新材料科技股份有限公司 | 2022-09-06 | — | — | CN | disclosed |
| CN-112813684-A | Low-dielectric electronic-grade glass fiber cloth and production method thereof | 河南光远新材料股份有限公司 | 2021-05-18 | — | — | CN | disclosed |
| US-4144351-A | ANTICHOLESTEROL | KLINGE PHARMA GMBH & CO. (DE) | 1979-03-13 | — | — | US | disclosed |
| US-4109013-A | SUBSTITUTED PROPANOL-(2) DERIVATIVES OF HYDROXAMIC ACIDS AND THE USE THEREOF AS HYPOLIPEMIC DRUGS | KLINGE PHARMA GMBH & CO. (DE) | 1978-08-22 | — | — | US | disclosed |
| US-4082780-A | ANTIESTROGEN DRUGS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JA) | 1978-04-04 | — | — | US | disclosed |
| US-4073935-A | Substituted propanol-(2)-derivatives and their nicotinic acid esters, and process for their preparation, and the use thereof as hypolipemic drugs | KLINGE PHARMA GMBH & CO. (DT) | 1978-02-14 | — | — | US | disclosed |