Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 2/20 | 0.43 |
| ▸ | GSK3A | P49840 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.39 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11503645 | 0.98 | CYP11B2 (0.42) | CYP11B2GSK3AGSK3BPABPC1APOBEC3A | |
| Hydrochloric Acid SCHEMBL2463206 | 0.91 | MMP3 (0.45) | CYP11B2KIF11MMP3CYP19A1HDAC8 | |
| SCHEMBL4325064 | 0.89 | MMP3 (0.46) | CYP11B2KIF11MMP3CYP19A1HDAC8 | |
| Bromide SCHEMBL10597082 | 0.87 | MMP3 (0.45) | CYP11B2KIF11MMP3CYP19A1HDAC8 | |
| SCHEMBL12216504 | 0.82 | MAPT (0.52) | CYP11B2PABPC1APOBEC3AEIF4HAPOBEC3G | |
| SCHEMBL6660002 | 0.81 | KIF11 (0.41) | CYP11B2KIF11MMP3HDAC8 | |
| SCHEMBL2568795 | 0.80 | CYP11B2 (0.61) | CYP11B2GSK3AGSK3BCYP11B1LMNA | |
| SCHEMBL13063634 | 0.80 | CYP11B2 (0.61) | CYP11B2GSK3AGSK3BCYP11B1LMNA | |
| SCHEMBL6660004 | 0.80 | KIF11 (0.40) | CYP11B2KIF11MMP3HDAC8 | |
| SCHEMBL19689478 | 0.80 | HDAC8 (0.61) | PABPC1APOBEC3AEIF4HAPOBEC3GKIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4109068-A | RADIATION SENSITIVE VINYL HYDROPHILIC COPOLYMERS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1978-08-22 | — | — | US | disclosed |