Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 4/20 | 0.51 |
| ▸ | CCND1 | P24385 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11386344 | 0.74 | CDK4 (0.60) | CDK4CCND1HTTALDH1A1LMNA | |
| Potassium Ion SCHEMBL11621862 | 0.73 | CDK4 (0.53) | CDK4CCND1HTTALDH1A1LMNA | |
| SCHEMBL11366447 | 0.71 | CDK4 (1.00) | CDK4CCND1HTTALDH1A1LMNA | |
| Potassium Ion SCHEMBL11621859 | 0.70 | CDK4 (0.56) | CDK4CCND1HTTALDH1A1LMNA | |
| SCHEMBL9358675 | 0.68 | CDK4 (0.63) | CDK4CCND1HTTALDH1A1LMNA | |
| SCHEMBL3134501 | 0.68 | CDK4 (0.76) | CDK4CCND1HTTALDH1A1LMNA | |
| SCHEMBL5428812 | 0.68 | HTT (0.60) | CDK4CCND1HTTALDH1A1LMNA | |
| SCHEMBL9491094 | 0.67 | CDK4 (0.62) | CDK4CCND1HTTALDH1A1LMNA | |
| SCHEMBL30418240 | 0.66 | CDK4 (0.66) | CDK4CCND1HTTALDH1A1LMNA | |
| SCHEMBL4078165 | 0.65 | CDK4 (0.63) | CDK4CCND1HTTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4066763-A | Thiazinoindoles useful as antidepressants | AYERST MCKENNA AND HARRISON LTD. (CA) | 1978-01-03 | — | — | US | disclosed |
| US-3962236-A | ANTIDEPRESSANTS, ANTI-ULCER | AYERST MCKENNA AND HARRISON LTD. (CA) | 1976-06-08 | — | — | US | disclosed |