SCHEMBL1162363

SCHEMBL1162363

O=C(Cl)c1ccc2nc(Cl)c(Cl)nc2c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDH1 P12830 1/20 0.47
APC P25054 1/20 0.47
CTNNB1 P35222 1/20 0.47
TCF7L2 Q9NQB0 1/20 0.47
TDP1 Q9NUW8 2/20 0.47
ALDH1A1 P00352 7/20 0.43
RAB9A P51151 5/20 0.43
HPGD P15428 5/20 0.43
MEN1 O00255 5/20 0.43
KMT2A Q03164 5/20 0.43
KDM4E B2RXH2 4/20 0.43
NPC1 O15118 3/20 0.43
GAA P10253 3/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
MAPT P10636 4/20 0.40
LMNA P02545 3/20 0.40
POLB P06746 2/20 0.38
L3MBTL1 Q9Y468 2/20 0.38
HTT P42858 2/20 0.38
PKM P14618 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18995950 0.88 TDP1 (0.57) CDH1APCCTNNB1TCF7L2TDP1
SCHEMBL2245346 0.86 TDP1 (0.48) CDH1APCCTNNB1TCF7L2TDP1
SCHEMBL12355762 0.86 TDP1 (0.48) CDH1APCCTNNB1TCF7L2TDP1
SCHEMBL22376192 0.84 CDH1 (0.47) CDH1APCCTNNB1TCF7L2TDP1
SCHEMBL10643646 0.84 TDP1 (0.67) CDH1APCCTNNB1TCF7L2TDP1
SCHEMBL9088640 0.82 CHEK2 (0.47) CDH1APCCTNNB1TCF7L2TDP1
SCHEMBL8502343 0.82 CDH1 (0.46) CDH1APCCTNNB1TCF7L2TDP1
Hydrochloric Acid SCHEMBL8591571 0.82 TDP1 (0.65) CDH1APCCTNNB1TCF7L2TDP1
SCHEMBL9091793 0.82 TDP1 (0.50) CDH1APCCTNNB1TCF7L2TDP1
SCHEMBL17184361 0.82 HPGD (0.63) CDH1APCCTNNB1TCF7L2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 118 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7105645-B2 Water-soluble fiber-reactive dyes, method for the production and use thereof DYSTAR TEXTILFARBEN GMBH & CO. DEUTSCHLAND KG (DE) 2006-09-12 US claimed
US-20050198748-A1 Copper complexes of monoazo dyes; diazotization of a sulfonyl-o-hydroxyaniline, coupling to a 1-hydroxy-3-sulfonate-6-aminonaphthalene, coppering with copper sulfate pentahydrate; improved washfastness, photostability, and compatibility with other dyes which fix at lower temperatures DYSTAR TEXTILFARBEN GMBH & CO. DEUTSCHLAND KG (DE) 2005-09-15 US claimed
US-4418015-A Phthalocyanine reactive dyestuffs BAYER AKTIENGESELLSCHAFT (DE) 1983-11-29 US claimed
JP-6306058-A None JP disclosed
WO-2025026556-A1 CROSSLINKERS PREFERE RESINS HOLDING GMBH (DE) 2025-02-06 WO disclosed
CN-111343963-B Use of physiologically cooling active ingredients and compositions comprising such active ingredients 巴斯夫欧洲公司 2023-09-12 CN disclosed
CN-214088352-U Aniline compound serialization production facility CHENGDA PHARMACEUTICALS CO LTD 2021-08-31 CN disclosed
CN-111343963-A Use of physiological cooling active ingredients and compositions comprising such active ingredients 巴斯夫欧洲公司 2020-06-26 CN disclosed
US-20200190052-A1 USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND COMPOSITIONS COMPRISING SUCH ACTIVE INGREDIENTS BASF SE (DE) 2020-06-18 US disclosed
US-20160058749-A1 TREATMENTS FOR NEUROPATHY CHILDRENS MEDICAL CENTER (US) 2016-03-03 US disclosed
US-20160045487-A1 COMPOSITIONS AND METHODS FOR TREATING NEUROPATHY NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2016-02-18 US disclosed
US-4051134-A Reactive dyestuffs BAYER AKTIENGESELLSCHAFT (DT) 1977-09-27 US disclosed
US-4049704-A AZO REACTIVE DYES BAYER AKTIENGESELLSCHAFT (DT) 1977-09-20 US disclosed
US-4025510-A DYES FOR POLYESTERS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1977-05-24 US disclosed
US-4024123-A TEXTILES DUSSY PAUL 1977-05-17 US disclosed
US-4022799-A DYEING, PRINTING OF NATURAL AND SYNTHETIC MATERIALS BAYER AKTIENGESELLSCHAFT (DT) 1977-05-10 US disclosed
US-3989692-A PHTHALOCYANINE DYES, WOOL, SILK, POLYAMIDES, CELLULOSE BAYER AKTIENGESELLSCHAFT (DT) 1976-11-02 US disclosed
US-3988310-A FIBER-REACTIVE DYES; CELLULOSE BAYER AKTIENGESELLSCHAFT (DT) 1976-10-26 US disclosed
US-3957751-A WATER-SOLUBLE REACTIVE DYESTUFFS OF THE MONOAZO SERIES CONTAINING AN ACTIVE METHYLENE COUPLING COMPONENT HOECHST AKTIENGESELLSCHAFT (DT) 1976-05-18 US disclosed
US-3950347-A NAPHTHOLACTAM DYESTUFFS BAYER AKTIENGESELLSCHAFT (DT) 1976-04-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160058749-A1 TREATMENTS FOR NEUROPATHY NGF, BDNF, NTRK2 CDH1 4340/4885APC 4448/4885CTNNB1 4305/4885
US-20160045487-A1 COMPOSITIONS AND METHODS FOR TREATING NEUROPATHY PMP22, GAP43, NGF CDH1 3998/4885APC 3805/4885CTNNB1 2366/4885
US-20200190052-A1 USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND COMPOSITIONS COMPRISING SUCH ACTIVE INGREDIENTS TRPM8, TRPM7, TRPM5 CDH1 4151/4885APC 4856/4885CTNNB1 4857/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.