Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.56 |
| ▸ | HTR2A | P28223 | 5/20 | 0.56 |
| ▸ | HTR6 | P50406 | 5/20 | 0.56 |
| ▸ | HTR7 | P34969 | 5/20 | 0.56 |
| ▸ | HTR1A | P08908 | 4/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.45 |
| ▸ | DRD1 | P21728 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11632645 | 0.92 | L3MBTL1 (0.50) | DRD2HTR2AHTR6HTR7HTR1A | |
| SCHEMBL11631804 | 0.90 | L3MBTL1 (0.59) | DRD2HTR2AHTR6HTR7HTR1A | |
| SCHEMBL11630691 | 0.90 | KDM4E (0.61) | DRD2HTR2AHTR6HTR7HTR1A | |
| SCHEMBL11629079 | 0.88 | L3MBTL1 (0.51) | DRD2HTR2AHTR6HTR7HTR1A | |
| SCHEMBL11632587 | 0.88 | L3MBTL1 (0.50) | DRD2HTR2AHTR6HTR7HTR1A | |
| SCHEMBL11631256 | 0.87 | HTR1A (0.62) | DRD2HTR2AHTR6HTR7HTR1A | |
| SCHEMBL11636824 | 0.86 | L3MBTL1 (0.49) | DRD2HTR2AHTR6HTR7HTR1A | |
| SCHEMBL11628968 | 0.85 | DRD2 (0.58) | DRD2HTR2AHTR6HTR7HTR1A | |
| SCHEMBL11631327 | 0.84 | L3MBTL1 (0.49) | DRD2HTR2AHTR6HTR7HTR1A | |
| SCHEMBL11635336 | 0.84 | HTR7 (0.58) | DRD2HTR2AHTR6HTR7HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4077958-A | ANTIDEPRESSANTS | E. R. SQUIBB & SONS, INC. (US) | 1978-03-07 | — | — | US | disclosed |
| US-4007191-A | ANTIDEPRESSANT | E. R. SQUIBB & SONS, INC. (US) | 1977-02-08 | — | — | US | disclosed |