Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 6/20 | 0.46 |
| ▸ | DRD2 | P14416 | 6/20 | 0.46 |
| ▸ | HTR2A | P28223 | 6/20 | 0.46 |
| ▸ | HTR6 | P50406 | 6/20 | 0.46 |
| ▸ | HTR7 | P34969 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11631804 | 0.89 | L3MBTL1 (0.59) | L3MBTL1LMNAKDM4EMAPK1HTR1A | |
| SCHEMBL11630691 | 0.88 | KDM4E (0.61) | L3MBTL1LMNAKDM4EMAPK1HTR1A | |
| SCHEMBL11629224 | 0.88 | DRD2 (0.56) | L3MBTL1LMNAKDM4EMAPK1HTR1A | |
| SCHEMBL11631256 | 0.87 | HTR1A (0.62) | L3MBTL1LMNAKDM4EHTR1ADRD2 | |
| SCHEMBL11636824 | 0.84 | L3MBTL1 (0.49) | L3MBTL1LMNAKDM4EMAPK1HTR1A | |
| SCHEMBL11632645 | 0.84 | L3MBTL1 (0.50) | L3MBTL1LMNAKDM4EMAPK1HTR1A | |
| SCHEMBL11635336 | 0.82 | HTR7 (0.58) | L3MBTL1LMNAKDM4EMAPK1HTR1A | |
| SCHEMBL11630627 | 0.82 | HTR7 (0.61) | L3MBTL1LMNAKDM4EMAPK1HTR1A | |
| SCHEMBL11835734 | 0.81 | KDM4E (0.65) | LMNAKDM4EMAPK1HTR1ADRD2 | |
| SCHEMBL11634483 | 0.81 | DRD4 (0.44) | L3MBTL1LMNAKDM4EMAPK1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4077958-A | ANTIDEPRESSANTS | E. R. SQUIBB & SONS, INC. (US) | 1978-03-07 | — | — | US | disclosed |
| US-4007191-A | ANTIDEPRESSANT | E. R. SQUIBB & SONS, INC. (US) | 1977-02-08 | — | — | US | disclosed |