Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.71 |
| ▸ | DRD2 | P14416 | 6/20 | 0.71 |
| ▸ | HTR2A | P28223 | 6/20 | 0.71 |
| ▸ | HTR6 | P50406 | 6/20 | 0.71 |
| ▸ | HTR7 | P34969 | 6/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.68 |
| ▸ | LMNA | P02545 | 3/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | HPGD | P15428 | 1/20 | 0.68 |
| ▸ | RAB9A | P51151 | 1/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.67 |
| ▸ | RAD52 | P43351 | 1/20 | 0.59 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.59 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | UBE2N | P61088 | 1/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11842208 | 0.90 | KDM4E (0.61) | HTR1ADRD2HTR2AHTR6HTR7 | |
| SCHEMBL11632287 | 0.88 | HTR7 (0.70) | HTR1ADRD2HTR2AHTR6HTR7 | |
| SCHEMBL11631848 | 0.88 | KDM4E (0.86) | HTR1ADRD2HTR2AHTR6HTR7 | |
| SCHEMBL11835734 | 0.85 | KDM4E (0.65) | HTR1ADRD2HTR2AHTR6HTR7 | |
| SCHEMBL11848412 | 0.85 | KDM4E (0.68) | KDM4ELMNAMAPTALDH1A1HPGD | |
| SCHEMBL11630516 | 0.85 | HTR7 (0.57) | HTR1ADRD2HTR2AHTR6HTR7 | |
| SCHEMBL11631571 | 0.84 | HTR1A (0.85) | HTR1ADRD2HTR2AHTR6HTR7 | |
| SCHEMBL11848610 | 0.83 | KDM4E (0.64) | HTR1ADRD2HTR2AHTR6HTR7 | |
| SCHEMBL11631324 | 0.82 | DRD2 (0.73) | HTR1ADRD2HTR2AHTR6HTR7 | |
| SCHEMBL11838631 | 0.81 | HTR1A (0.57) | HTR1ADRD2HTR2AHTR6HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3940397-A | ANTIINFLAMMATORY | E. R. SQUIBB & SONS, INC. (US) | 1976-02-24 | — | — | US | claimed |
| US-4077958-A | ANTIDEPRESSANTS | E. R. SQUIBB & SONS, INC. (US) | 1978-03-07 | — | — | US | disclosed |
| US-4007191-A | ANTIDEPRESSANT | E. R. SQUIBB & SONS, INC. (US) | 1977-02-08 | — | — | US | disclosed |
| US-3940397-A | ANTIINFLAMMATORY | E. R. SQUIBB & SONS, INC. (US) | 1976-02-24 | — | — | US | disclosed |