Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 7/20 | 0.64 |
| ▸ | DRD2 | P14416 | 7/20 | 0.64 |
| ▸ | HTR1A | P08908 | 6/20 | 0.64 |
| ▸ | HTR2A | P28223 | 6/20 | 0.64 |
| ▸ | HTR6 | P50406 | 6/20 | 0.64 |
| ▸ | DRD3 | P35462 | 4/20 | 0.54 |
| ▸ | DRD1 | P21728 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | CASP1 | P29466 | 1/20 | 0.54 |
| ▸ | CASP7 | P55210 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11629816 | 0.98 | HTR7 (0.67) | HTR7DRD2HTR1AHTR2AHTR6 | |
| SCHEMBL11632015 | 0.94 | HTR7 (0.60) | HTR7DRD2HTR1AHTR2AHTR6 | |
| SCHEMBL11635336 | 0.86 | HTR7 (0.58) | HTR7DRD2HTR1AHTR2AHTR6 | |
| SCHEMBL11630627 | 0.84 | HTR7 (0.61) | HTR7DRD2HTR1AHTR2AHTR6 | |
| SCHEMBL11631804 | 0.79 | L3MBTL1 (0.59) | HTR7DRD2HTR1AHTR2AHTR6 | |
| SCHEMBL11632064 | 0.79 | HTR1A (0.98) | HTR7DRD2HTR1AHTR2AHTR6 | |
| SCHEMBL11633522 | 0.79 | L3MBTL1 (0.47) | HTR7DRD2DRD3L3MBTL1 | |
| SCHEMBL11845169 | 0.78 | HTR1A (1.00) | HTR7DRD2HTR1AHTR2AHTR6 | |
| SCHEMBL11835918 | 0.78 | HTR1A (1.00) | HTR7DRD2HTR1AHTR2AHTR6 | |
| SCHEMBL11633867 | 0.78 | L3MBTL1 (0.54) | HTR7KDM4EMAPTL3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4077958-A | ANTIDEPRESSANTS | E. R. SQUIBB & SONS, INC. (US) | 1978-03-07 | — | — | US | disclosed |
| US-4007191-A | ANTIDEPRESSANT | E. R. SQUIBB & SONS, INC. (US) | 1977-02-08 | — | — | US | disclosed |